Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations
Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was condu...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-11-01
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| Series: | Rare Tumors |
| Online Access: | https://doi.org/10.1177/2036361320973526 |
| _version_ | 1818666474676420608 |
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| author | Silvia Mezi Giulia Pomati Andrea Botticelli Francesca De Felice Daniela Musio Marco della Monaca Sasan Amirhassankhani Francesco Vullo Bruna Cerbelli Raffaella Carletti Cira Di Gioia Carlo Catalano Valentino Valentini Vincenzo Tombolini Carlo Della Rocca Paolo Marchetti |
| author_facet | Silvia Mezi Giulia Pomati Andrea Botticelli Francesca De Felice Daniela Musio Marco della Monaca Sasan Amirhassankhani Francesco Vullo Bruna Cerbelli Raffaella Carletti Cira Di Gioia Carlo Catalano Valentino Valentini Vincenzo Tombolini Carlo Della Rocca Paolo Marchetti |
| author_sort | Silvia Mezi |
| collection | DOAJ |
| description | Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results. |
| first_indexed | 2024-12-17T06:05:06Z |
| format | Article |
| id | doaj.art-d14197239fd64c5a948b6def47e73d5d |
| institution | Directory Open Access Journal |
| issn | 2036-3613 |
| language | English |
| last_indexed | 2024-12-17T06:05:06Z |
| publishDate | 2020-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-d14197239fd64c5a948b6def47e73d5d2022-12-21T22:00:46ZengSAGE PublishingRare Tumors2036-36132020-11-011210.1177/2036361320973526Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendationsSilvia Mezi0Giulia Pomati1Andrea Botticelli2Francesca De Felice3Daniela Musio4Marco della Monaca5Sasan Amirhassankhani6Francesco Vullo7Bruna Cerbelli8Raffaella Carletti9Cira Di Gioia10Carlo Catalano11Valentino Valentini12Vincenzo Tombolini13Carlo Della Rocca14Paolo Marchetti15Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Clinical and Molecular Medicine, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Odontostomatological and Maxillo-Facial Science “Sapienza” University of Rome, Rome, ItalyMSc Guy’s & St Thomas’ NHS Foundation Trust, London, UKDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Odontostomatological and Maxillo-Facial Science “Sapienza” University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, ItalyDepartment of Clinical and Molecular Medicine, “Sapienza” University of Rome, Rome, ItalyPrimary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results.https://doi.org/10.1177/2036361320973526 |
| spellingShingle | Silvia Mezi Giulia Pomati Andrea Botticelli Francesca De Felice Daniela Musio Marco della Monaca Sasan Amirhassankhani Francesco Vullo Bruna Cerbelli Raffaella Carletti Cira Di Gioia Carlo Catalano Valentino Valentini Vincenzo Tombolini Carlo Della Rocca Paolo Marchetti Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations Rare Tumors |
| title | Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations |
| title_full | Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations |
| title_fullStr | Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations |
| title_full_unstemmed | Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations |
| title_short | Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations |
| title_sort | primary squamous cell carcinoma of major salivary gland sapienza head and neck unit clinical recommendations |
| url | https://doi.org/10.1177/2036361320973526 |
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