About a Rare Association Between Vulvar Dowling Degos Disease and HS
Manon Dupont,1 Muriel Parent,2 Olivier Vanhooteghem1 1Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Namur, 5000, Belgium; 2Department of Pathology, Institute of Pathology and Genetics (IPG), Gosselies, 6041, BelgiumCorrespondence: Olivier Vanhooteghem, Email ovanhooteghem@hotmail.com...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-03-01
|
| Series: | International Journal of Women's Health |
| Subjects: | |
| Online Access: | https://www.dovepress.com/about-a-rare-association-between-vulvar-dowling-degos-disease-and-hs-peer-reviewed-fulltext-article-IJWH |
| _version_ | 1827996783014313984 |
|---|---|
| author | Dupont M Parent M Vanhooteghem O |
| author_facet | Dupont M Parent M Vanhooteghem O |
| author_sort | Dupont M |
| collection | DOAJ |
| description | Manon Dupont,1 Muriel Parent,2 Olivier Vanhooteghem1 1Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Namur, 5000, Belgium; 2Department of Pathology, Institute of Pathology and Genetics (IPG), Gosselies, 6041, BelgiumCorrespondence: Olivier Vanhooteghem, Email ovanhooteghem@hotmail.comAbstract: Dowling Degos disease (DDD) is a rare genodermatosis that manifests itself as acquired, reticulated hyperpigmentation of the folds. We report the case of a 45-year-old woman who presented since the age of 30 with hyperpigmented macules of reticulated appearance of vulvar, perianal and bilateral axillary location associated with hidradenitis suppurativa (HS) at Hurley stage 2 of later onset. DDD is classically described in the flexural folds and, to our knowledge; less than a dozen cases of vulvar location are published in the literature. We postulate that DDD is responsible for the development of HS in susceptible patients. Indeed, this association seems to be explained by a common pathophysiological mechanism, targeting the Notch signalling pathway, involved in the proliferation and differentiation of epidermal cells that can induce the development of HS. DDD should be considered as a comorbid factor of HS.Keywords: hidradenitis suppurativa, Dowling Degos, vulvar, hyperpigmentation, comorbidities |
| first_indexed | 2024-04-10T05:17:25Z |
| format | Article |
| id | doaj.art-d142af95ee744d389a4f60818eb23c0c |
| institution | Directory Open Access Journal |
| issn | 1179-1411 |
| language | English |
| last_indexed | 2024-04-10T05:17:25Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Women's Health |
| spelling | doaj.art-d142af95ee744d389a4f60818eb23c0c2023-03-08T18:01:00ZengDove Medical PressInternational Journal of Women's Health1179-14112023-03-01Volume 1535535982117About a Rare Association Between Vulvar Dowling Degos Disease and HSDupont MParent MVanhooteghem OManon Dupont,1 Muriel Parent,2 Olivier Vanhooteghem1 1Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Namur, 5000, Belgium; 2Department of Pathology, Institute of Pathology and Genetics (IPG), Gosselies, 6041, BelgiumCorrespondence: Olivier Vanhooteghem, Email ovanhooteghem@hotmail.comAbstract: Dowling Degos disease (DDD) is a rare genodermatosis that manifests itself as acquired, reticulated hyperpigmentation of the folds. We report the case of a 45-year-old woman who presented since the age of 30 with hyperpigmented macules of reticulated appearance of vulvar, perianal and bilateral axillary location associated with hidradenitis suppurativa (HS) at Hurley stage 2 of later onset. DDD is classically described in the flexural folds and, to our knowledge; less than a dozen cases of vulvar location are published in the literature. We postulate that DDD is responsible for the development of HS in susceptible patients. Indeed, this association seems to be explained by a common pathophysiological mechanism, targeting the Notch signalling pathway, involved in the proliferation and differentiation of epidermal cells that can induce the development of HS. DDD should be considered as a comorbid factor of HS.Keywords: hidradenitis suppurativa, Dowling Degos, vulvar, hyperpigmentation, comorbiditieshttps://www.dovepress.com/about-a-rare-association-between-vulvar-dowling-degos-disease-and-hs-peer-reviewed-fulltext-article-IJWHhidradenitis suppurativadowling degosvulvarhyperpigmentationcomorbidities. |
| spellingShingle | Dupont M Parent M Vanhooteghem O About a Rare Association Between Vulvar Dowling Degos Disease and HS International Journal of Women's Health hidradenitis suppurativa dowling degos vulvar hyperpigmentation comorbidities. |
| title | About a Rare Association Between Vulvar Dowling Degos Disease and HS |
| title_full | About a Rare Association Between Vulvar Dowling Degos Disease and HS |
| title_fullStr | About a Rare Association Between Vulvar Dowling Degos Disease and HS |
| title_full_unstemmed | About a Rare Association Between Vulvar Dowling Degos Disease and HS |
| title_short | About a Rare Association Between Vulvar Dowling Degos Disease and HS |
| title_sort | about a rare association between vulvar dowling degos disease and hs |
| topic | hidradenitis suppurativa dowling degos vulvar hyperpigmentation comorbidities. |
| url | https://www.dovepress.com/about-a-rare-association-between-vulvar-dowling-degos-disease-and-hs-peer-reviewed-fulltext-article-IJWH |
| work_keys_str_mv | AT dupontm aboutarareassociationbetweenvulvardowlingdegosdiseaseandhs AT parentm aboutarareassociationbetweenvulvardowlingdegosdiseaseandhs AT vanhooteghemo aboutarareassociationbetweenvulvardowlingdegosdiseaseandhs |