Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in developing new options that can efficiently tackle the...
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MDPI AG
2022-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1429 |
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| author | Walther Bild Alexandru Vasincu Răzvan-Nicolae Rusu Daniela-Carmen Ababei Aurelian Bogdan Stana Gabriela Dumitrița Stanciu Bogdan Savu Veronica Bild |
| author_facet | Walther Bild Alexandru Vasincu Răzvan-Nicolae Rusu Daniela-Carmen Ababei Aurelian Bogdan Stana Gabriela Dumitrița Stanciu Bogdan Savu Veronica Bild |
| author_sort | Walther Bild |
| collection | DOAJ |
| description | Brain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in developing new options that can efficiently tackle the different components and pathophysiological processes of these conditions. The renin-angiotensin-aldosterone system (RAS) is an endocrine axis with important peripheral physiological functions such as blood pressure and cardiovascular homeostasis, as well as water and sodium balance and systemic vascular resistance—functions which are well-documented. However, recent work has highlighted the paracrine and autocrine functions of RAS in different tissues, including the central nervous system (CNS). It is known that RAS hyperactivation has pro-inflammatory and pro-oxidant effects, thus suggesting that its pharmacological modulation could be used in the management of these conditions. The present paper underlines the involvement of RAS and its components in the pathophysiology of BNDs such as Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS), Huntington’s disease (HD), motor neuron disease (MND), and prion disease (PRD), as well as the identification of drugs and pharmacologically active substances that act upon RAS, which could alleviate their symptomatology or evolution, and thus, contribute to novel therapeutic approaches. |
| first_indexed | 2024-03-09T20:37:22Z |
| format | Article |
| id | doaj.art-d14306f6f50545d1b3ae7fee100c6058 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:37:22Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d14306f6f50545d1b3ae7fee100c60582023-11-23T23:08:32ZengMDPI AGBiomolecules2218-273X2022-10-011210142910.3390/biom12101429Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative DiseasesWalther Bild0Alexandru Vasincu1Răzvan-Nicolae Rusu2Daniela-Carmen Ababei3Aurelian Bogdan Stana4Gabriela Dumitrița Stanciu5Bogdan Savu6Veronica Bild7Department of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Pharmacodynamics and Clinical Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Pharmacodynamics and Clinical Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Pharmacodynamics and Clinical Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaCenter for Advanced Research and Development in Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Pediatric Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaCenter of Biomedical Research of the Romanian Academy, 700506 Iasi, RomaniaBrain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in developing new options that can efficiently tackle the different components and pathophysiological processes of these conditions. The renin-angiotensin-aldosterone system (RAS) is an endocrine axis with important peripheral physiological functions such as blood pressure and cardiovascular homeostasis, as well as water and sodium balance and systemic vascular resistance—functions which are well-documented. However, recent work has highlighted the paracrine and autocrine functions of RAS in different tissues, including the central nervous system (CNS). It is known that RAS hyperactivation has pro-inflammatory and pro-oxidant effects, thus suggesting that its pharmacological modulation could be used in the management of these conditions. The present paper underlines the involvement of RAS and its components in the pathophysiology of BNDs such as Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS), Huntington’s disease (HD), motor neuron disease (MND), and prion disease (PRD), as well as the identification of drugs and pharmacologically active substances that act upon RAS, which could alleviate their symptomatology or evolution, and thus, contribute to novel therapeutic approaches.https://www.mdpi.com/2218-273X/12/10/1429neurodegenerativereninangiotensin (1–7)brain RASAlzheimer’sHuntington’s |
| spellingShingle | Walther Bild Alexandru Vasincu Răzvan-Nicolae Rusu Daniela-Carmen Ababei Aurelian Bogdan Stana Gabriela Dumitrița Stanciu Bogdan Savu Veronica Bild Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases Biomolecules neurodegenerative renin angiotensin (1–7) brain RAS Alzheimer’s Huntington’s |
| title | Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases |
| title_full | Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases |
| title_fullStr | Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases |
| title_full_unstemmed | Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases |
| title_short | Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases |
| title_sort | impact of the renin angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases |
| topic | neurodegenerative renin angiotensin (1–7) brain RAS Alzheimer’s Huntington’s |
| url | https://www.mdpi.com/2218-273X/12/10/1429 |
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