Structural and functional changes of the cerebellum in temporal lobe epilepsy
AimsThis study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information.MethodsThe SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the avera...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1213224/full |
| _version_ | 1797755312122363904 |
|---|---|
| author | Ge Wang Ge Wang Ge Wang Xianghe Liu Xianghe Liu Xianghe Liu Min Zhang Min Zhang Min Zhang Kangrun Wang Kangrun Wang Kangrun Wang Chaorong Liu Chaorong Liu Chaorong Liu Yayu Chen Yayu Chen Yayu Chen Wenyue Wu Wenyue Wu Haiting Zhao Haiting Zhao Haiting Zhao Bo Xiao Bo Xiao Bo Xiao Lily Wan Lili Long Lili Long Lili Long |
| author_facet | Ge Wang Ge Wang Ge Wang Xianghe Liu Xianghe Liu Xianghe Liu Min Zhang Min Zhang Min Zhang Kangrun Wang Kangrun Wang Kangrun Wang Chaorong Liu Chaorong Liu Chaorong Liu Yayu Chen Yayu Chen Yayu Chen Wenyue Wu Wenyue Wu Haiting Zhao Haiting Zhao Haiting Zhao Bo Xiao Bo Xiao Bo Xiao Lily Wan Lili Long Lili Long Lili Long |
| author_sort | Ge Wang |
| collection | DOAJ |
| description | AimsThis study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information.MethodsThe SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the average diffusion values of cerebellar peduncle tracts to investigate microstructure alterations. Seed-based whole-brain analysis was used to investigate cerebellar–cerebral functional connectivity (FC). Subgroup analyses were performed to identify the cerebellar participation in TLE with/without hippocampal sclerosis (HS)/focal-to-bilateral tonic–clonic seizure (FBTCS) and TLE with different lateralization.ResultsTLE showed widespread gray matter atrophy in bilateral crusII, VIIb, VIIIb, left crusI, and left VIIIa. Both voxel and tract analysis observed diffusion abnormalities in cerebellar afferent peduncles. Reduced FC between the right crus II and the left parahippocampal cortex was found in TLE. Additionally, TLE showed increased FCs between left lobules VI–VIII and cortical nodes of the dorsal attention and visual networks. Across all patients, decreased FC was associated with poorer cognitive function, while increased FCs appeared to reflect compensatory effects. The cerebellar structural changes were mainly observed in HS and FBTCS subgroups and were regardless of seizure lateralization, while cerebellar–cerebral FC alterations were similar in all subgroups.ConclusionTLE exhibited microstructural changes in the cerebellum, mainly related to HS and FBTCS. In addition, altered cerebellar–cerebral functional connectivity is associated with common cognitive alterations in TLE. |
| first_indexed | 2024-03-12T17:45:02Z |
| format | Article |
| id | doaj.art-d143aa16b3fe4cf4b31500cacf192ce4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T17:45:02Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d143aa16b3fe4cf4b31500cacf192ce42023-08-03T17:42:15ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.12132241213224Structural and functional changes of the cerebellum in temporal lobe epilepsyGe Wang0Ge Wang1Ge Wang2Xianghe Liu3Xianghe Liu4Xianghe Liu5Min Zhang6Min Zhang7Min Zhang8Kangrun Wang9Kangrun Wang10Kangrun Wang11Chaorong Liu12Chaorong Liu13Chaorong Liu14Yayu Chen15Yayu Chen16Yayu Chen17Wenyue Wu18Wenyue Wu19Haiting Zhao20Haiting Zhao21Haiting Zhao22Bo Xiao23Bo Xiao24Bo Xiao25Lily Wan26Lili Long27Lili Long28Lili Long29Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, ChinaAimsThis study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information.MethodsThe SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the average diffusion values of cerebellar peduncle tracts to investigate microstructure alterations. Seed-based whole-brain analysis was used to investigate cerebellar–cerebral functional connectivity (FC). Subgroup analyses were performed to identify the cerebellar participation in TLE with/without hippocampal sclerosis (HS)/focal-to-bilateral tonic–clonic seizure (FBTCS) and TLE with different lateralization.ResultsTLE showed widespread gray matter atrophy in bilateral crusII, VIIb, VIIIb, left crusI, and left VIIIa. Both voxel and tract analysis observed diffusion abnormalities in cerebellar afferent peduncles. Reduced FC between the right crus II and the left parahippocampal cortex was found in TLE. Additionally, TLE showed increased FCs between left lobules VI–VIII and cortical nodes of the dorsal attention and visual networks. Across all patients, decreased FC was associated with poorer cognitive function, while increased FCs appeared to reflect compensatory effects. The cerebellar structural changes were mainly observed in HS and FBTCS subgroups and were regardless of seizure lateralization, while cerebellar–cerebral FC alterations were similar in all subgroups.ConclusionTLE exhibited microstructural changes in the cerebellum, mainly related to HS and FBTCS. In addition, altered cerebellar–cerebral functional connectivity is associated with common cognitive alterations in TLE.https://www.frontiersin.org/articles/10.3389/fneur.2023.1213224/fullcerebellar pedunclecerebellumfunctional connectivitymultimodality MRItemporal lobe epilepsy |
| spellingShingle | Ge Wang Ge Wang Ge Wang Xianghe Liu Xianghe Liu Xianghe Liu Min Zhang Min Zhang Min Zhang Kangrun Wang Kangrun Wang Kangrun Wang Chaorong Liu Chaorong Liu Chaorong Liu Yayu Chen Yayu Chen Yayu Chen Wenyue Wu Wenyue Wu Haiting Zhao Haiting Zhao Haiting Zhao Bo Xiao Bo Xiao Bo Xiao Lily Wan Lili Long Lili Long Lili Long Structural and functional changes of the cerebellum in temporal lobe epilepsy Frontiers in Neurology cerebellar peduncle cerebellum functional connectivity multimodality MRI temporal lobe epilepsy |
| title | Structural and functional changes of the cerebellum in temporal lobe epilepsy |
| title_full | Structural and functional changes of the cerebellum in temporal lobe epilepsy |
| title_fullStr | Structural and functional changes of the cerebellum in temporal lobe epilepsy |
| title_full_unstemmed | Structural and functional changes of the cerebellum in temporal lobe epilepsy |
| title_short | Structural and functional changes of the cerebellum in temporal lobe epilepsy |
| title_sort | structural and functional changes of the cerebellum in temporal lobe epilepsy |
| topic | cerebellar peduncle cerebellum functional connectivity multimodality MRI temporal lobe epilepsy |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1213224/full |
| work_keys_str_mv | AT gewang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT gewang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT gewang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT xiangheliu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT xiangheliu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT xiangheliu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT minzhang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT minzhang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT minzhang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT kangrunwang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT kangrunwang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT kangrunwang structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT chaorongliu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT chaorongliu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT chaorongliu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT yayuchen structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT yayuchen structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT yayuchen structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT wenyuewu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT wenyuewu structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT haitingzhao structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT haitingzhao structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT haitingzhao structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT boxiao structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT boxiao structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT boxiao structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT lilywan structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT lililong structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT lililong structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy AT lililong structuralandfunctionalchangesofthecerebellumintemporallobeepilepsy |