Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

<p>Abstract</p> <p>Background</p> <p>Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue cataly...

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Bibliographic Details
Main Authors: Saxena Deepti, Palumbo Paul, Hanauske-Abel Hartmut M, Hoque Mainul, D'Alliessi Gandolfi Darlene, Park Myung, Pe'ery Tsafi, Mathews Michael B
Format: Article
Language:English
Published: BMC 2009-10-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/6/1/90

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