Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus)
Abstract Background The aim of this study was to analyze potential influences of polymorphisms within the regulatory region of the bovine SIRT6 gene on carcass quality traits. Expression analyses suggested that SIRT6 gene is predominately expressed in kidney, compared with other tissues. In 535 indi...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Genomics |
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| Online Access: | http://link.springer.com/article/10.1186/s12864-018-5149-0 |
| _version_ | 1819023161633538048 |
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| author | Lin-sheng Gui Sayed Haidar Abbas Raza Matthew Garcia Yong-gang Sun Irfan Ullah Yin-cang Han |
| author_facet | Lin-sheng Gui Sayed Haidar Abbas Raza Matthew Garcia Yong-gang Sun Irfan Ullah Yin-cang Han |
| author_sort | Lin-sheng Gui |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to analyze potential influences of polymorphisms within the regulatory region of the bovine SIRT6 gene on carcass quality traits. Expression analyses suggested that SIRT6 gene is predominately expressed in kidney, compared with other tissues. In 535 indigenous Chinese beef cattle, two novel single nucleotide polymorphisms (SNPs) were identified within the promoter region of the SIRT6 gene. Results Association analysis indicated that G allele of the c.-1100 A > G had a positive effect on fat deposition, and the Hap4/4 diplotype had more favourable results than other dipoltypes with respect to the evaluation of carcass quality traits. Furthermore, promoter activity associated with the Hap3 haplotype was measured at higher levels than the Hap1 haplotype, which would be in agreement with the previously described association analysis. Conclusion The SIRT6 promoter variants significantly affect transcriptional levels and subsequently significantly influence bovine intramscular fat content. |
| first_indexed | 2024-12-21T04:34:30Z |
| format | Article |
| id | doaj.art-d147088e88164c29b2a76f744ae91cdc |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-21T04:34:30Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-d147088e88164c29b2a76f744ae91cdc2022-12-21T19:15:53ZengBMCBMC Genomics1471-21642018-11-011911710.1186/s12864-018-5149-0Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus)Lin-sheng Gui0Sayed Haidar Abbas Raza1Matthew Garcia2Yong-gang Sun3Irfan Ullah4Yin-cang Han5State Key Laboratory of Plateau Ecology and Agriculture, Qinghai UniversityCollege of Animal Science and Technology, Northwest A&F UniversityUtah State University, School of Animal Dairy and Veterinary SciencesAcademy of Animal Science and Veterinary Medicine, Qinghai UniversityCollege of Bio-medical engineering Chongqing University ChongqingAcademy of Animal Science and Veterinary Medicine, Qinghai UniversityAbstract Background The aim of this study was to analyze potential influences of polymorphisms within the regulatory region of the bovine SIRT6 gene on carcass quality traits. Expression analyses suggested that SIRT6 gene is predominately expressed in kidney, compared with other tissues. In 535 indigenous Chinese beef cattle, two novel single nucleotide polymorphisms (SNPs) were identified within the promoter region of the SIRT6 gene. Results Association analysis indicated that G allele of the c.-1100 A > G had a positive effect on fat deposition, and the Hap4/4 diplotype had more favourable results than other dipoltypes with respect to the evaluation of carcass quality traits. Furthermore, promoter activity associated with the Hap3 haplotype was measured at higher levels than the Hap1 haplotype, which would be in agreement with the previously described association analysis. Conclusion The SIRT6 promoter variants significantly affect transcriptional levels and subsequently significantly influence bovine intramscular fat content.http://link.springer.com/article/10.1186/s12864-018-5149-0Transcription factorSIRT6Fat depositionExpression pattern |
| spellingShingle | Lin-sheng Gui Sayed Haidar Abbas Raza Matthew Garcia Yong-gang Sun Irfan Ullah Yin-cang Han Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus) BMC Genomics Transcription factor SIRT6 Fat deposition Expression pattern |
| title | Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus) |
| title_full | Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus) |
| title_fullStr | Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus) |
| title_full_unstemmed | Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus) |
| title_short | Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus) |
| title_sort | genetic variants in the sirt6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous chinese beef cattle bos taurus |
| topic | Transcription factor SIRT6 Fat deposition Expression pattern |
| url | http://link.springer.com/article/10.1186/s12864-018-5149-0 |
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