Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women
Objective: Comparing oxytocin level and some other parameters between infertile women with or without polycystic Ovary Syndrome (PCOS), to evaluate the correlation between oxytocin with anti-mullerian hormone (AMH), Body Mass Index (BMI) and insulin resistance (IR). Materials and methods: This cross...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455918301335 |
| _version_ | 1819111539805782016 |
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| author | Bahia Namavar Jahromi Mohammad Hossein Dabbaghmanesh Pardis Bakhshaie Mohammad Ebrahim Parsanezhad Zahra Anvar Mahshid Alborzi Afsoon Zarei Mina Bakhshaei |
| author_facet | Bahia Namavar Jahromi Mohammad Hossein Dabbaghmanesh Pardis Bakhshaie Mohammad Ebrahim Parsanezhad Zahra Anvar Mahshid Alborzi Afsoon Zarei Mina Bakhshaei |
| author_sort | Bahia Namavar Jahromi |
| collection | DOAJ |
| description | Objective: Comparing oxytocin level and some other parameters between infertile women with or without polycystic Ovary Syndrome (PCOS), to evaluate the correlation between oxytocin with anti-mullerian hormone (AMH), Body Mass Index (BMI) and insulin resistance (IR). Materials and methods: This cross–sectional study was performed on 80 PCOS and 81 non-PCOS women as the control group. Oxytocin, various hormones, Oral glucose tolerance test (OGTT) and Homeostatic model assessment of insulin resistance (HOMA-IR) were compared between two groups. Correlations between parameters were assessed by the spearman's rank correlation coefficient. Cutoff values for oxytocin and AMH in PCOS were calculated by the ROC-Curve and DeLong method. Results: The mean oxytocin level was statistically lower in the case group (p ≤ 0.001). The mean BMI, AMH, HOMA-IR, fasting insulin and insulin 2-h after 75-g glucose were significantly higher in the PCOS group. Oxytocin was negatively correlated to AMH when evaluated for all participants or only among controls. Moreover oxytocin was negatively correlated to HOMA-IR among all participants. However the relationship between oxytocin and BMI was not statistically significant. The calculated cutoff value for oxytocin was 125 ng/L and for AMH was 3.6 ng/mL in the PCOS group. Conclusion: The mean oxytocin level in the PCOS infertile women was lower than non-PCOS women. Oxytocin showed a significant reverse correlation with AMH and HOMA-IR. Keywords: Polycystic ovary syndrome, Oxytocin, Anti-mullerian hormone, Oral glucose tolerance test (OGTT) |
| first_indexed | 2024-12-22T03:59:14Z |
| format | Article |
| id | doaj.art-d14850352b974777a7a10a78e38d6f7b |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-22T03:59:14Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-d14850352b974777a7a10a78e38d6f7b2022-12-21T18:39:48ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592018-08-01574555559Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS womenBahia Namavar Jahromi0Mohammad Hossein Dabbaghmanesh1Pardis Bakhshaie2Mohammad Ebrahim Parsanezhad3Zahra Anvar4Mahshid Alborzi5Afsoon Zarei6Mina Bakhshaei7Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Maternal-fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding authors. Department of Obstetrics and Gynecology, Shahid Faghihi hospital, Zand street, P.O.BOX: 7134846114, Shiraz, Iran.Endocrinology & Metabolism Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Center, Shiraz University of Medical Sciences, Shiraz, IranInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding authors. Department of Obstetrics and Gynecology, Shahid Faghihi hospital, Zand street, P.O.BOX: 7134846114, Shiraz, Iran.Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, Jahrom University of Medical Sciences, Jahrom, IranInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Biophysics, Science and Research Branch, Islamic Azad University, Tehran, IranObjective: Comparing oxytocin level and some other parameters between infertile women with or without polycystic Ovary Syndrome (PCOS), to evaluate the correlation between oxytocin with anti-mullerian hormone (AMH), Body Mass Index (BMI) and insulin resistance (IR). Materials and methods: This cross–sectional study was performed on 80 PCOS and 81 non-PCOS women as the control group. Oxytocin, various hormones, Oral glucose tolerance test (OGTT) and Homeostatic model assessment of insulin resistance (HOMA-IR) were compared between two groups. Correlations between parameters were assessed by the spearman's rank correlation coefficient. Cutoff values for oxytocin and AMH in PCOS were calculated by the ROC-Curve and DeLong method. Results: The mean oxytocin level was statistically lower in the case group (p ≤ 0.001). The mean BMI, AMH, HOMA-IR, fasting insulin and insulin 2-h after 75-g glucose were significantly higher in the PCOS group. Oxytocin was negatively correlated to AMH when evaluated for all participants or only among controls. Moreover oxytocin was negatively correlated to HOMA-IR among all participants. However the relationship between oxytocin and BMI was not statistically significant. The calculated cutoff value for oxytocin was 125 ng/L and for AMH was 3.6 ng/mL in the PCOS group. Conclusion: The mean oxytocin level in the PCOS infertile women was lower than non-PCOS women. Oxytocin showed a significant reverse correlation with AMH and HOMA-IR. Keywords: Polycystic ovary syndrome, Oxytocin, Anti-mullerian hormone, Oral glucose tolerance test (OGTT)http://www.sciencedirect.com/science/article/pii/S1028455918301335 |
| spellingShingle | Bahia Namavar Jahromi Mohammad Hossein Dabbaghmanesh Pardis Bakhshaie Mohammad Ebrahim Parsanezhad Zahra Anvar Mahshid Alborzi Afsoon Zarei Mina Bakhshaei Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women Taiwanese Journal of Obstetrics & Gynecology |
| title | Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women |
| title_full | Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women |
| title_fullStr | Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women |
| title_full_unstemmed | Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women |
| title_short | Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women |
| title_sort | assessment of oxytocin level glucose metabolism components and cutoff values for oxytocin and anti mullerian hormone in infertile pcos women |
| url | http://www.sciencedirect.com/science/article/pii/S1028455918301335 |
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