Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease
Pneumonitis from leflunomide is uncommon due to leflunomide's relatively favorable drug profile. Leflunomide-induced pneumonitis (LEIP) is a rare condition reported mainly in Asia. We present a case of LEIP from an accidental leflunomide overdose in the setting of concomitant methotrexate use a...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007121001301 |
| _version_ | 1818354454012887040 |
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| author | V.D. Villgran E. Rabold A. Nasrullah B. Disilvio O. Bajwa |
| author_facet | V.D. Villgran E. Rabold A. Nasrullah B. Disilvio O. Bajwa |
| author_sort | V.D. Villgran |
| collection | DOAJ |
| description | Pneumonitis from leflunomide is uncommon due to leflunomide's relatively favorable drug profile. Leflunomide-induced pneumonitis (LEIP) is a rare condition reported mainly in Asia. We present a case of LEIP from an accidental leflunomide overdose in the setting of concomitant methotrexate use and no underlying lung disease. Our patient was treated successfully with cholestyramine and steroids. Due to its high mortality, clinicians should be aware of this condition and its treatment. |
| first_indexed | 2024-12-13T19:25:40Z |
| format | Article |
| id | doaj.art-d14c62c280dc4f1abc43fc8c9e24fc0d |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-13T19:25:40Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-d14c62c280dc4f1abc43fc8c9e24fc0d2022-12-21T23:34:02ZengElsevierRespiratory Medicine Case Reports2213-00712021-01-0133101468Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung diseaseV.D. Villgran0E. Rabold1A. Nasrullah2B. Disilvio3O. Bajwa4Pulmonary & Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, United States; Corresponding author. Pulmonary & Critical Care Fellow – PGY5, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA, 15212, United States.Pulmonary & Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, United StatesInternal Medicine, Allegheny Health Network, Pittsburgh, PA, United StatesPulmonary & Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, United StatesPulmonary & Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, United StatesPneumonitis from leflunomide is uncommon due to leflunomide's relatively favorable drug profile. Leflunomide-induced pneumonitis (LEIP) is a rare condition reported mainly in Asia. We present a case of LEIP from an accidental leflunomide overdose in the setting of concomitant methotrexate use and no underlying lung disease. Our patient was treated successfully with cholestyramine and steroids. Due to its high mortality, clinicians should be aware of this condition and its treatment.http://www.sciencedirect.com/science/article/pii/S2213007121001301LeflunomidePneumonitisMethotrexateInterstitial lung diseaseAdverse event |
| spellingShingle | V.D. Villgran E. Rabold A. Nasrullah B. Disilvio O. Bajwa Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease Respiratory Medicine Case Reports Leflunomide Pneumonitis Methotrexate Interstitial lung disease Adverse event |
| title | Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease |
| title_full | Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease |
| title_fullStr | Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease |
| title_full_unstemmed | Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease |
| title_short | Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease |
| title_sort | leflunomide induced interstitial pneumonitis a rare occurrence in a case without underlying lung disease |
| topic | Leflunomide Pneumonitis Methotrexate Interstitial lung disease Adverse event |
| url | http://www.sciencedirect.com/science/article/pii/S2213007121001301 |
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