Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we...
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MDPI AG
2013-09-01
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Online Access: | http://www.mdpi.com/2072-6651/5/9/1655 |
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author | Jens Laurids Sørensen Henriette Giese |
author_facet | Jens Laurids Sørensen Henriette Giese |
author_sort | Jens Laurids Sørensen |
collection | DOAJ |
description | Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides (arabinose, xylose, fructose, sorbose, galactose, mannose, glucose), five disaccharides (cellobiose, lactose, maltose, sucrose and trehalose) and three polysaccharides (dextrin, inulin and xylan) were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis. |
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language | English |
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series | Toxins |
spelling | doaj.art-d14d3ea656ec4208bdf3a9f1f242c1782022-12-22T03:58:34ZengMDPI AGToxins2072-66512013-09-01591655166310.3390/toxins5091655Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceumJens Laurids SørensenHenriette GieseFusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides (arabinose, xylose, fructose, sorbose, galactose, mannose, glucose), five disaccharides (cellobiose, lactose, maltose, sucrose and trehalose) and three polysaccharides (dextrin, inulin and xylan) were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis.http://www.mdpi.com/2072-6651/5/9/1655secondary metabolitesmoniliforminenniatincarbonregulationactivationcreA |
spellingShingle | Jens Laurids Sørensen Henriette Giese Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum Toxins secondary metabolites moniliformin enniatin carbon regulation activation creA |
title | Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum |
title_full | Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum |
title_fullStr | Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum |
title_full_unstemmed | Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum |
title_short | Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum |
title_sort | influence of carbohydrates on secondary metabolism in fusarium avenaceum |
topic | secondary metabolites moniliformin enniatin carbon regulation activation creA |
url | http://www.mdpi.com/2072-6651/5/9/1655 |
work_keys_str_mv | AT jenslauridssørensen influenceofcarbohydratesonsecondarymetabolisminfusariumavenaceum AT henriettegiese influenceofcarbohydratesonsecondarymetabolisminfusariumavenaceum |