Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum

Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we...

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Main Authors: Jens Laurids Sørensen, Henriette Giese
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/5/9/1655
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author Jens Laurids Sørensen
Henriette Giese
author_facet Jens Laurids Sørensen
Henriette Giese
author_sort Jens Laurids Sørensen
collection DOAJ
description Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides (arabinose, xylose, fructose, sorbose, galactose, mannose, glucose), five disaccharides (cellobiose, lactose, maltose, sucrose and trehalose) and three polysaccharides (dextrin, inulin and xylan) were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis.
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spelling doaj.art-d14d3ea656ec4208bdf3a9f1f242c1782022-12-22T03:58:34ZengMDPI AGToxins2072-66512013-09-01591655166310.3390/toxins5091655Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceumJens Laurids SørensenHenriette GieseFusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides (arabinose, xylose, fructose, sorbose, galactose, mannose, glucose), five disaccharides (cellobiose, lactose, maltose, sucrose and trehalose) and three polysaccharides (dextrin, inulin and xylan) were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis.http://www.mdpi.com/2072-6651/5/9/1655secondary metabolitesmoniliforminenniatincarbonregulationactivationcreA
spellingShingle Jens Laurids Sørensen
Henriette Giese
Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
Toxins
secondary metabolites
moniliformin
enniatin
carbon
regulation
activation
creA
title Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
title_full Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
title_fullStr Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
title_full_unstemmed Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
title_short Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
title_sort influence of carbohydrates on secondary metabolism in fusarium avenaceum
topic secondary metabolites
moniliformin
enniatin
carbon
regulation
activation
creA
url http://www.mdpi.com/2072-6651/5/9/1655
work_keys_str_mv AT jenslauridssørensen influenceofcarbohydratesonsecondarymetabolisminfusariumavenaceum
AT henriettegiese influenceofcarbohydratesonsecondarymetabolisminfusariumavenaceum