Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer

Abstract Background Increasing evidence suggests that immunotherapy, especially immune checkpoint inhibitors (ICIs), has the potential to facilitate long-term survival in various cancer besides prostate cancer. Emerging evidence indicated that pyroptosis, an immunogenic form of cell death, could tri...

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Bibliographic Details
Main Authors: Fei Wu, Minglei Wang, Tao Zhong, Changyan Xiao, Xiaozheng Chen, Yiheng Huang, Meng Wu, Jinming Yu, Dawei Chen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Experimental Hematology & Oncology
Subjects:
CDC20
GSDME
Immunotherapy
Prostate cancer
Pyroptosis
Online Access:https://doi.org/10.1186/s40164-023-00428-9

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