Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release
Abstract Stretchable hydrogels have been used for a number of biomedical applications. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications. Four drug compounds, nicotine, lidocaine hydrochlori...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2021-01-01
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| Series: | Nano Select |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/nano.202000087 |
| _version_ | 1818741329388109824 |
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| author | Zhen Qiao Long Tran Jesse Parks Yao Zhao Nan Hai Yinghui Zhong Hai‐Feng Ji |
| author_facet | Zhen Qiao Long Tran Jesse Parks Yao Zhao Nan Hai Yinghui Zhong Hai‐Feng Ji |
| author_sort | Zhen Qiao |
| collection | DOAJ |
| description | Abstract Stretchable hydrogels have been used for a number of biomedical applications. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications. Four drug compounds, nicotine, lidocaine hydrochloride, diltiazem hydrochloride and diclofenac sodium, were used for the evaluation. The release rates of these compounds follow an order: lidocaine > diltiazem > nicotine > diclofenac, which showed a strong correlation between the release rate with their solubility in water at pH 5.5. The kinetics study showed a linear and sustainable release of all tested drugs in the first 8 hours. Experiments were conducted in vitro on replicated human skin. Cytotoxicity studies indicate hydrogel is nontoxic to human cells. The highly stretchable and tough characters of the hydrogel the strength of the hydrogel reduce the severity of wear and tear issues over time for transdermal drug release. |
| first_indexed | 2024-12-18T01:54:54Z |
| format | Article |
| id | doaj.art-d14de408ac8b4a5d866533f8e978ad09 |
| institution | Directory Open Access Journal |
| issn | 2688-4011 |
| language | English |
| last_indexed | 2024-12-18T01:54:54Z |
| publishDate | 2021-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Nano Select |
| spelling | doaj.art-d14de408ac8b4a5d866533f8e978ad092022-12-21T21:24:56ZengWiley-VCHNano Select2688-40112021-01-012110711510.1002/nano.202000087Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug releaseZhen Qiao0Long Tran1Jesse Parks2Yao Zhao3Nan Hai4Yinghui Zhong5Hai‐Feng Ji6Department of Chemistry Drexel University Philadelphia Pennsylvania 19104 USADepartment of Chemistry Drexel University Philadelphia Pennsylvania 19104 USADepartment of Chemistry Drexel University Philadelphia Pennsylvania 19104 USASchool of Biomedical Engineering Science and Health Systems Drexel University Philadelphia Pennsylvania 19104 USASchool of Biomedical Engineering Science and Health Systems Drexel University Philadelphia Pennsylvania 19104 USASchool of Biomedical Engineering Science and Health Systems Drexel University Philadelphia Pennsylvania 19104 USADepartment of Chemistry Drexel University Philadelphia Pennsylvania 19104 USAAbstract Stretchable hydrogels have been used for a number of biomedical applications. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications. Four drug compounds, nicotine, lidocaine hydrochloride, diltiazem hydrochloride and diclofenac sodium, were used for the evaluation. The release rates of these compounds follow an order: lidocaine > diltiazem > nicotine > diclofenac, which showed a strong correlation between the release rate with their solubility in water at pH 5.5. The kinetics study showed a linear and sustainable release of all tested drugs in the first 8 hours. Experiments were conducted in vitro on replicated human skin. Cytotoxicity studies indicate hydrogel is nontoxic to human cells. The highly stretchable and tough characters of the hydrogel the strength of the hydrogel reduce the severity of wear and tear issues over time for transdermal drug release.https://doi.org/10.1002/nano.202000087chemical crosslinkingdrug deliveryhighly stretchablehydrogelphysical crosslinkingpolyacrylamide |
| spellingShingle | Zhen Qiao Long Tran Jesse Parks Yao Zhao Nan Hai Yinghui Zhong Hai‐Feng Ji Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release Nano Select chemical crosslinking drug delivery highly stretchable hydrogel physical crosslinking polyacrylamide |
| title | Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release |
| title_full | Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release |
| title_fullStr | Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release |
| title_full_unstemmed | Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release |
| title_short | Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release |
| title_sort | highly stretchable gelatin polyacrylamide hydrogel for potential transdermal drug release |
| topic | chemical crosslinking drug delivery highly stretchable hydrogel physical crosslinking polyacrylamide |
| url | https://doi.org/10.1002/nano.202000087 |
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