Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways
Detection of pathogen-derived DNA or RNA species by cellular nucleic acid sensors prompts release of anti-microbial interferons and cytokines. In contrast to their protective anti-microbial functions, inappropriate or excessive activation of nucleic acid sensors can cause inflammatory diseases. Nucl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.635738/full |
| _version_ | 1819168583145488384 |
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| author | Julia Blay-Cadanet Alice Pedersen Christian Kanstrup Holm |
| author_facet | Julia Blay-Cadanet Alice Pedersen Christian Kanstrup Holm |
| author_sort | Julia Blay-Cadanet |
| collection | DOAJ |
| description | Detection of pathogen-derived DNA or RNA species by cellular nucleic acid sensors prompts release of anti-microbial interferons and cytokines. In contrast to their protective anti-microbial functions, inappropriate or excessive activation of nucleic acid sensors can cause inflammatory diseases. Nucleic acid sensing is therefore tightly controlled by regulatory factors acting through both transcriptional and post-transcriptional mechanisms. Recently, it has become clearer that metabolic pathways—previously thought to be unconnected with immune responses—can influence nucleic acid sensing. This regulation can be observed when immune system cells undergo metabolic reprogramming in response to stimulation with pathogen-associated molecular patterns such as lipopolysaccharide from gram negative bacteria. Metabolic reprogramming leads to accumulation and secretion of metabolites, which have been mostly viewed as end-products of processes providing cellular energy and building blocks. However, metabolites have now been identified as important regulators of nucleic acid sensing. This mini-review aims to outline current knowledge on regulation of central nucleic acid sensing pathways by metabolites during metabolic reprogramming. |
| first_indexed | 2024-12-22T19:05:54Z |
| format | Article |
| id | doaj.art-d1514a1ed6c84c3e98e47441005af5f4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T19:05:54Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d1514a1ed6c84c3e98e47441005af5f42022-12-21T18:15:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011210.3389/fimmu.2021.635738635738Cellular Metabolites Regulate Central Nucleic Acid Sensing PathwaysJulia Blay-CadanetAlice PedersenChristian Kanstrup HolmDetection of pathogen-derived DNA or RNA species by cellular nucleic acid sensors prompts release of anti-microbial interferons and cytokines. In contrast to their protective anti-microbial functions, inappropriate or excessive activation of nucleic acid sensors can cause inflammatory diseases. Nucleic acid sensing is therefore tightly controlled by regulatory factors acting through both transcriptional and post-transcriptional mechanisms. Recently, it has become clearer that metabolic pathways—previously thought to be unconnected with immune responses—can influence nucleic acid sensing. This regulation can be observed when immune system cells undergo metabolic reprogramming in response to stimulation with pathogen-associated molecular patterns such as lipopolysaccharide from gram negative bacteria. Metabolic reprogramming leads to accumulation and secretion of metabolites, which have been mostly viewed as end-products of processes providing cellular energy and building blocks. However, metabolites have now been identified as important regulators of nucleic acid sensing. This mini-review aims to outline current knowledge on regulation of central nucleic acid sensing pathways by metabolites during metabolic reprogramming.https://www.frontiersin.org/articles/10.3389/fimmu.2021.635738/fullmetaboliteslactatesuccinateitaconateMAVSSTING |
| spellingShingle | Julia Blay-Cadanet Alice Pedersen Christian Kanstrup Holm Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways Frontiers in Immunology metabolites lactate succinate itaconate MAVS STING |
| title | Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways |
| title_full | Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways |
| title_fullStr | Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways |
| title_full_unstemmed | Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways |
| title_short | Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways |
| title_sort | cellular metabolites regulate central nucleic acid sensing pathways |
| topic | metabolites lactate succinate itaconate MAVS STING |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.635738/full |
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