An overview of ion channels therapeutics in the treatment of pain
Significance of the study: The clinical management of severe and chronic pain relies heavily on opioids that cause serious side-effects. There therefore exists an urgent need to develop safer and effective analgesics. Moreover, there has been significant progress in the understanding of pain physiol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223006421 |
| _version_ | 1797690956231737344 |
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| author | Yahya I. Asiri Mohd. Zaheen Hassan |
| author_facet | Yahya I. Asiri Mohd. Zaheen Hassan |
| author_sort | Yahya I. Asiri |
| collection | DOAJ |
| description | Significance of the study: The clinical management of severe and chronic pain relies heavily on opioids that cause serious side-effects. There therefore exists an urgent need to develop safer and effective analgesics. Moreover, there has been significant progress in the understanding of pain physiology, especially the role of some ion channels in the pain process. Thus, the immense potential of ion channel therapeutics in pain management is a subject of current interest. Aim of the study: This study is a comprehensive review, focused on ion channels as potential therapeutic targets for the treatment of pain. Research methodology: A systemic search of available literature on ion channels analgesics was performed. Articles related to the drug discovery and clinical trials on relevant topics were extracted from PubMed and other databases. Major conclusion of the study: Small molecules targeted at ion channels pathways hold great promise for creating a new approach to pain treatment. Several molecules targeting TRPV1, TRPV3, TRPV4, TRPA1, TRPM8, Nav1.7, Nav1.8, CaV2.2, CaV3.2, ASIC, and P2X3 have demonstrated potential clinical benefits. However, till date US FDA has approved capsaicin, ziconotide, and pregabalin for the treatment of different pain conditions. This review highlights the possibilities for discovery and research on ion channels and their potential for pain treatment. |
| first_indexed | 2024-03-12T02:06:35Z |
| format | Article |
| id | doaj.art-d151d4e1f6f945f4996029faa3ae0701 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-12T02:06:35Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-d151d4e1f6f945f4996029faa3ae07012023-09-07T04:43:40ZengElsevierArabian Journal of Chemistry1878-53522023-10-011610105180An overview of ion channels therapeutics in the treatment of painYahya I. Asiri0Mohd. Zaheen Hassan1Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; Corresponding author at: Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.Significance of the study: The clinical management of severe and chronic pain relies heavily on opioids that cause serious side-effects. There therefore exists an urgent need to develop safer and effective analgesics. Moreover, there has been significant progress in the understanding of pain physiology, especially the role of some ion channels in the pain process. Thus, the immense potential of ion channel therapeutics in pain management is a subject of current interest. Aim of the study: This study is a comprehensive review, focused on ion channels as potential therapeutic targets for the treatment of pain. Research methodology: A systemic search of available literature on ion channels analgesics was performed. Articles related to the drug discovery and clinical trials on relevant topics were extracted from PubMed and other databases. Major conclusion of the study: Small molecules targeted at ion channels pathways hold great promise for creating a new approach to pain treatment. Several molecules targeting TRPV1, TRPV3, TRPV4, TRPA1, TRPM8, Nav1.7, Nav1.8, CaV2.2, CaV3.2, ASIC, and P2X3 have demonstrated potential clinical benefits. However, till date US FDA has approved capsaicin, ziconotide, and pregabalin for the treatment of different pain conditions. This review highlights the possibilities for discovery and research on ion channels and their potential for pain treatment.http://www.sciencedirect.com/science/article/pii/S1878535223006421AnalgesicsIon ChannelsTransient receptor potential channelsSodium channelsAnd calcium channels |
| spellingShingle | Yahya I. Asiri Mohd. Zaheen Hassan An overview of ion channels therapeutics in the treatment of pain Arabian Journal of Chemistry Analgesics Ion Channels Transient receptor potential channels Sodium channels And calcium channels |
| title | An overview of ion channels therapeutics in the treatment of pain |
| title_full | An overview of ion channels therapeutics in the treatment of pain |
| title_fullStr | An overview of ion channels therapeutics in the treatment of pain |
| title_full_unstemmed | An overview of ion channels therapeutics in the treatment of pain |
| title_short | An overview of ion channels therapeutics in the treatment of pain |
| title_sort | overview of ion channels therapeutics in the treatment of pain |
| topic | Analgesics Ion Channels Transient receptor potential channels Sodium channels And calcium channels |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223006421 |
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