The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats
Abstract Background and Objectives: Chemerin is a novel adipokine, which plays a key role in the pathological process of insulin resistance and inflammation; clinical studies have shown that chemerin levels increase in diabetic patients. However, the acute effect of exercise on chemerin is not kn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2016-11-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| Subjects: | |
| Online Access: | http://journal.muq.ac.ir/browse.php?a_code=A-10-1-559&slc_lang=en&sid=1 |
| _version_ | 1818722758634242048 |
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| author | Mousa Khalafi Shabkhiz Fatemeh Shabkhiz Mohammadreza Zolfaghari Yashar Zarei |
| author_facet | Mousa Khalafi Shabkhiz Fatemeh Shabkhiz Mohammadreza Zolfaghari Yashar Zarei |
| author_sort | Mousa Khalafi |
| collection | DOAJ |
| description | Abstract
Background and Objectives: Chemerin is a novel adipokine, which plays a key role in the pathological process of insulin resistance and inflammation; clinical studies have shown that chemerin levels increase in diabetic patients. However, the acute effect of exercise on chemerin is not known. In this research, serum changes of chemerin in diabetic male rats were investigated in response to two types of exercise.
Methods: In this experimental study, 29 diabetic male rats (age, 12 weeks; weight, 220-240g) were assigned to 5 groups, including immediately and 2 hours after high-intensity interval exercise (HIIE0, HIIE2), immediately and 2 hours after moderate-intensity continuous exercise (MICE0, MICE2), and control (C). Both MICE groups exercise on treadmill (intensity, 60-65% vo2max) for 40 min, and both HIIE groups (with intensity of 90-95% vo2max) in 12 one-minute intervals with one-minute rest intervals. ELISA technique was used to measure serum chemerin. Data were analyzed using one-way ANOVA and post-hoc Tukey's test. The level of significance was considered at 0.05.
Results: Serum chemerin levels in MICE0, MICE2 groups and HIIE2 groups, significantly increased compared to the control group (p˂0.05). However, there was no significant difference between HIIE0 group and control group (p>0.05). There was significant difference between MICE0 and HIIE2 groups with HIIE0 group (p˂0.05).
Conclusion: The results of the present research showed that acute exercise leads to increase in serum chemerin in diabetic male rats.
Keywords: Chemerin protein, rat; Exercise; Diabetes mellitus. |
| first_indexed | 2024-12-17T20:59:43Z |
| format | Article |
| id | doaj.art-d151d96b865340169cd2aa79a61088b1 |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-17T20:59:43Z |
| publishDate | 2016-11-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-d151d96b865340169cd2aa79a61088b12022-12-21T21:32:47ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752016-11-011082735The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male RatsMousa Khalafi0Shabkhiz Fatemeh Shabkhiz1Mohammadreza Zolfaghari2Yashar Zarei3 University of Guilan University of Tehran University of Urmia University of Tehran Abstract Background and Objectives: Chemerin is a novel adipokine, which plays a key role in the pathological process of insulin resistance and inflammation; clinical studies have shown that chemerin levels increase in diabetic patients. However, the acute effect of exercise on chemerin is not known. In this research, serum changes of chemerin in diabetic male rats were investigated in response to two types of exercise. Methods: In this experimental study, 29 diabetic male rats (age, 12 weeks; weight, 220-240g) were assigned to 5 groups, including immediately and 2 hours after high-intensity interval exercise (HIIE0, HIIE2), immediately and 2 hours after moderate-intensity continuous exercise (MICE0, MICE2), and control (C). Both MICE groups exercise on treadmill (intensity, 60-65% vo2max) for 40 min, and both HIIE groups (with intensity of 90-95% vo2max) in 12 one-minute intervals with one-minute rest intervals. ELISA technique was used to measure serum chemerin. Data were analyzed using one-way ANOVA and post-hoc Tukey's test. The level of significance was considered at 0.05. Results: Serum chemerin levels in MICE0, MICE2 groups and HIIE2 groups, significantly increased compared to the control group (p˂0.05). However, there was no significant difference between HIIE0 group and control group (p>0.05). There was significant difference between MICE0 and HIIE2 groups with HIIE0 group (p˂0.05). Conclusion: The results of the present research showed that acute exercise leads to increase in serum chemerin in diabetic male rats. Keywords: Chemerin protein, rat; Exercise; Diabetes mellitus.http://journal.muq.ac.ir/browse.php?a_code=A-10-1-559&slc_lang=en&sid=1chemerin protein rat exercise diabetes mellitus |
| spellingShingle | Mousa Khalafi Shabkhiz Fatemeh Shabkhiz Mohammadreza Zolfaghari Yashar Zarei The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum chemerin protein rat exercise diabetes mellitus |
| title | The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats |
| title_full | The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats |
| title_fullStr | The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats |
| title_full_unstemmed | The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats |
| title_short | The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats |
| title_sort | effect of two types of exercise on serum chemerin in diabetic male rats |
| topic | chemerin protein rat exercise diabetes mellitus |
| url | http://journal.muq.ac.ir/browse.php?a_code=A-10-1-559&slc_lang=en&sid=1 |
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