| Summary: | <p>Abstract</p> <p>Objective</p> <p>To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.</p> <p>Method</p> <p>We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (<it>n</it> = 133), ramipril 1.25 mg/day (<it>n</it> = 133), or placebo (<it>n</it> = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.</p> <p>Results</p> <p>Relevant baseline variables were similar in all groups. Changes over 6 months in duration of ≥ 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.</p> <p>Conclusion</p> <p>ACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.</p>
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