No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months
<p>Abstract</p> <p>Objective</p> <p>To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.</p> <p>Method</p> <p>We randomized 389 patients with stable coronary artery disease to doub...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2001-04-01
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| Series: | Current Controlled Trials in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | http://cvm.controlled-trials.com/content/2/2/099 |
| _version_ | 1818498045968384000 |
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| author | Forslund Lennart Juul-Möller Steen Willenheimer Ronnie Erhardt Leif |
| author_facet | Forslund Lennart Juul-Möller Steen Willenheimer Ronnie Erhardt Leif |
| author_sort | Forslund Lennart |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.</p> <p>Method</p> <p>We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (<it>n</it> = 133), ramipril 1.25 mg/day (<it>n</it> = 133), or placebo (<it>n</it> = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.</p> <p>Results</p> <p>Relevant baseline variables were similar in all groups. Changes over 6 months in duration of ≥ 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.</p> <p>Conclusion</p> <p>ACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.</p> |
| first_indexed | 2024-12-10T18:52:57Z |
| format | Article |
| id | doaj.art-d152164df92442a2858e3be83802702d |
| institution | Directory Open Access Journal |
| issn | 1468-6708 |
| language | English |
| last_indexed | 2024-12-10T18:52:57Z |
| publishDate | 2001-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Current Controlled Trials in Cardiovascular Medicine |
| spelling | doaj.art-d152164df92442a2858e3be83802702d2022-12-22T01:37:16ZengBMCCurrent Controlled Trials in Cardiovascular Medicine1468-67082001-04-01229910510.1186/cvm-2-2-099No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 monthsForslund LennartJuul-Möller SteenWillenheimer RonnieErhardt Leif<p>Abstract</p> <p>Objective</p> <p>To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.</p> <p>Method</p> <p>We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (<it>n</it> = 133), ramipril 1.25 mg/day (<it>n</it> = 133), or placebo (<it>n</it> = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.</p> <p>Results</p> <p>Relevant baseline variables were similar in all groups. Changes over 6 months in duration of ≥ 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.</p> <p>Conclusion</p> <p>ACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.</p>http://cvm.controlled-trials.com/content/2/2/099angiotensin-converting enzyme inhibitorischaemic heart diseaseambulatory electrocardiographymyocardial ischaemia |
| spellingShingle | Forslund Lennart Juul-Möller Steen Willenheimer Ronnie Erhardt Leif No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months Current Controlled Trials in Cardiovascular Medicine angiotensin-converting enzyme inhibitor ischaemic heart disease ambulatory electrocardiography myocardial ischaemia |
| title | No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months |
| title_full | No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months |
| title_fullStr | No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months |
| title_full_unstemmed | No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months |
| title_short | No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months |
| title_sort | no effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months |
| topic | angiotensin-converting enzyme inhibitor ischaemic heart disease ambulatory electrocardiography myocardial ischaemia |
| url | http://cvm.controlled-trials.com/content/2/2/099 |
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