Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change
Abstract We sought to investigate changes in choroidal hemodynamics in preeclampsia according to presence of retinal change by quantitatively assessing choroidal vessels using optical coherence tomography (OCT). This retrospective study included 106 eyes (of 53 patients) with preeclampsia, including...
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40144-2 |
| _version_ | 1797560147593134080 |
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| author | In Kee Kim Jae Eun Shin Min Jeong Kim Ho Ra Jiwon Baek |
| author_facet | In Kee Kim Jae Eun Shin Min Jeong Kim Ho Ra Jiwon Baek |
| author_sort | In Kee Kim |
| collection | DOAJ |
| description | Abstract We sought to investigate changes in choroidal hemodynamics in preeclampsia according to presence of retinal change by quantitatively assessing choroidal vessels using optical coherence tomography (OCT). This retrospective study included 106 eyes (of 53 patients) with preeclampsia, including 70 eyes without retinal change in patients with preeclampsia (Group A), 22 eyes with retinal change in patients with preeclampsia (Group B), and 14 eyes of normal pregnant women (controls). Subfoveal choroidal thickness (SFCT) was measured on OCT B-scan images, and choroidal vessel densities (CVDs) were calculated using binarized OCT B-scan and en face images. Their values were then correlated with clinical parameters associated with preeclampsia. SFCT was greater in Group B compared to Group A or controls (354.32 ± 65.13 vs. 288 ± 55.68 or 277.21 ± 50.08, both P < 0.001). CVD on B-scan images was greater in Group B compared to Group A or controls (76.4 ± 4.9 vs. 73.7 ± 5.3 or 71.5 ± 5.1; both P ≤ 0.046). CVD on en face images was also greater in Group B compared to Group A or controls (64.7 ± 0.8 vs. 63.6 ± 1.5 or 63.3 ± 1.3; both P ≤ 0.001). SFCT and CVD positively correlated with each other (P ≤ 0.009) and were greater in patients with blurred vision and vaginal bleeding (P ≤ 0.020 for blurred vision and P ≤ 0.024 for vaginal bleeding). SFCT and CVDs were higher in preeclampsia patients with retinal change compared to those without retinal change or controls. Both SFCT and CVD showed association with blurred vision and vaginal bleeding. |
| first_indexed | 2024-03-10T17:55:13Z |
| format | Article |
| id | doaj.art-d153d72bdd154a81af39f3c9fc76388a |
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| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:55:13Z |
| publishDate | 2023-08-01 |
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| series | Scientific Reports |
| spelling | doaj.art-d153d72bdd154a81af39f3c9fc76388a2023-11-20T09:13:08ZengNature PortfolioScientific Reports2045-23222023-08-011311810.1038/s41598-023-40144-2Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal changeIn Kee Kim0Jae Eun Shin1Min Jeong Kim2Ho Ra3Jiwon Baek4Department of Ophthalmology, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Ophthalmology, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Ophthalmology, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of KoreaAbstract We sought to investigate changes in choroidal hemodynamics in preeclampsia according to presence of retinal change by quantitatively assessing choroidal vessels using optical coherence tomography (OCT). This retrospective study included 106 eyes (of 53 patients) with preeclampsia, including 70 eyes without retinal change in patients with preeclampsia (Group A), 22 eyes with retinal change in patients with preeclampsia (Group B), and 14 eyes of normal pregnant women (controls). Subfoveal choroidal thickness (SFCT) was measured on OCT B-scan images, and choroidal vessel densities (CVDs) were calculated using binarized OCT B-scan and en face images. Their values were then correlated with clinical parameters associated with preeclampsia. SFCT was greater in Group B compared to Group A or controls (354.32 ± 65.13 vs. 288 ± 55.68 or 277.21 ± 50.08, both P < 0.001). CVD on B-scan images was greater in Group B compared to Group A or controls (76.4 ± 4.9 vs. 73.7 ± 5.3 or 71.5 ± 5.1; both P ≤ 0.046). CVD on en face images was also greater in Group B compared to Group A or controls (64.7 ± 0.8 vs. 63.6 ± 1.5 or 63.3 ± 1.3; both P ≤ 0.001). SFCT and CVD positively correlated with each other (P ≤ 0.009) and were greater in patients with blurred vision and vaginal bleeding (P ≤ 0.020 for blurred vision and P ≤ 0.024 for vaginal bleeding). SFCT and CVDs were higher in preeclampsia patients with retinal change compared to those without retinal change or controls. Both SFCT and CVD showed association with blurred vision and vaginal bleeding.https://doi.org/10.1038/s41598-023-40144-2 |
| spellingShingle | In Kee Kim Jae Eun Shin Min Jeong Kim Ho Ra Jiwon Baek Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change Scientific Reports |
| title | Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change |
| title_full | Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change |
| title_fullStr | Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change |
| title_full_unstemmed | Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change |
| title_short | Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change |
| title_sort | quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change |
| url | https://doi.org/10.1038/s41598-023-40144-2 |
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