The relationship of Adiponctin / Leptin ratio with metabolic syndrome
Background: Metabolic syndrome is a cluster of risk factors for atherosclerotic cardiovascular disease caused by abdominal obesity, such as hyperglycemia, hypertension, dyslipidemia, and insulin resistance.Adiponectin is a protein hormone that modulates a number of metabolic processes, including glu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2012-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/779 |
| Summary: | Background: Metabolic syndrome is a cluster of risk factors for atherosclerotic cardiovascular disease caused by abdominal obesity, such as hyperglycemia, hypertension, dyslipidemia, and insulin resistance.Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acidcatabolism. Adiponectin is exclusively secreted from adipose tissue into the bloodstream. Leptin, a hormone synthesized by fat tissue had been noted to regulate energy balance and metabolism.In this study investigated the relationships of adiponectin/leptin ratio with metabolic syndrome in apparently healthy Iraqi male adults.
Objective: This study was designed to investigate the relationship of adiponectin/leptin ratio with metabolic syndrome in apparently healthy Iraqi male adults.
Methods: Ninety male subjects were enrolled in study (mean age, 40.97 ± 7.94 years). Serum leptin level and adiponectin level were measured using an enzyme-linked immunosorbent assay. And the presence of metabolic syndrome was assessed.
Results: Mean leptinlevel was significantly higher (7.29 ± 0.38 ng/ml), whileadiponectin andadiponectin/leptinratio was significantly lower(4.78 ± 0.24 μg/ml; 0.74 ± 0.07) respectively in
subjects with MS. With increasingnumber of metabolic syndrome components, the mean values of leptinincreased and the adiponectin andadiponectin/leptindecreased.
Conclusion: adiponectin/leptinratio correlated well with the presence and number of metabolic syndrome components in Iraqi male subjects. |
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| ISSN: | 0041-9419 2410-8057 |