Geminivirus-Derived Vectors as Tools for Functional Genomics
A persistent issue in the agricultural sector worldwide is the intensive damage caused to crops by the geminivirus family of viruses. The diverse types of viruses, rapid virus evolution rate, and broad host range make this group of viruses one of the most devastating in nature, leading to millions o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.799345/full |
| _version_ | 1818754572675448832 |
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| author | Bipasha Bhattacharjee Bipasha Bhattacharjee Vipin Hallan Vipin Hallan |
| author_facet | Bipasha Bhattacharjee Bipasha Bhattacharjee Vipin Hallan Vipin Hallan |
| author_sort | Bipasha Bhattacharjee |
| collection | DOAJ |
| description | A persistent issue in the agricultural sector worldwide is the intensive damage caused to crops by the geminivirus family of viruses. The diverse types of viruses, rapid virus evolution rate, and broad host range make this group of viruses one of the most devastating in nature, leading to millions of dollars’ worth of crop damage. Geminiviruses have a small genome and can be either monopartite or bipartite, with or without satellites. Their ability to independently replicate within the plant without integration into the host genome and the relatively easy handling make them excellent candidates for plant bioengineering. This aspect is of great importance as geminiviruses can act as natural nanoparticles in plants which can be utilized for a plethora of functions ranging from vaccine development systems to geminivirus-induced gene silencing (GIGS), through deconstructed viral vectors. Thus, the investigation of these plant viruses is pertinent to understanding their crucial roles in nature and subsequently utilizing them as beneficial tools in functional genomics. This review, therefore, highlights some of the characteristics of these viruses that can be deemed significant and the subsequent successful case studies for exploitation of these potentially significant pathogens for role mining in functional biology. |
| first_indexed | 2024-12-18T05:25:23Z |
| format | Article |
| id | doaj.art-d157c7c982f5478689070d9b57d50f26 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-18T05:25:23Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-d157c7c982f5478689070d9b57d50f262022-12-21T21:19:34ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-04-011310.3389/fmicb.2022.799345799345Geminivirus-Derived Vectors as Tools for Functional GenomicsBipasha Bhattacharjee0Bipasha Bhattacharjee1Vipin Hallan2Vipin Hallan3Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaPlant Virology Laboratory, Division of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, IndiaPlant Virology Laboratory, Division of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaA persistent issue in the agricultural sector worldwide is the intensive damage caused to crops by the geminivirus family of viruses. The diverse types of viruses, rapid virus evolution rate, and broad host range make this group of viruses one of the most devastating in nature, leading to millions of dollars’ worth of crop damage. Geminiviruses have a small genome and can be either monopartite or bipartite, with or without satellites. Their ability to independently replicate within the plant without integration into the host genome and the relatively easy handling make them excellent candidates for plant bioengineering. This aspect is of great importance as geminiviruses can act as natural nanoparticles in plants which can be utilized for a plethora of functions ranging from vaccine development systems to geminivirus-induced gene silencing (GIGS), through deconstructed viral vectors. Thus, the investigation of these plant viruses is pertinent to understanding their crucial roles in nature and subsequently utilizing them as beneficial tools in functional genomics. This review, therefore, highlights some of the characteristics of these viruses that can be deemed significant and the subsequent successful case studies for exploitation of these potentially significant pathogens for role mining in functional biology.https://www.frontiersin.org/articles/10.3389/fmicb.2022.799345/fullgeminivirussilencing systemcrop improvementCRISPR/Cas9biopharmaceuticalsviral vector |
| spellingShingle | Bipasha Bhattacharjee Bipasha Bhattacharjee Vipin Hallan Vipin Hallan Geminivirus-Derived Vectors as Tools for Functional Genomics Frontiers in Microbiology geminivirus silencing system crop improvement CRISPR/Cas9 biopharmaceuticals viral vector |
| title | Geminivirus-Derived Vectors as Tools for Functional Genomics |
| title_full | Geminivirus-Derived Vectors as Tools for Functional Genomics |
| title_fullStr | Geminivirus-Derived Vectors as Tools for Functional Genomics |
| title_full_unstemmed | Geminivirus-Derived Vectors as Tools for Functional Genomics |
| title_short | Geminivirus-Derived Vectors as Tools for Functional Genomics |
| title_sort | geminivirus derived vectors as tools for functional genomics |
| topic | geminivirus silencing system crop improvement CRISPR/Cas9 biopharmaceuticals viral vector |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.799345/full |
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