Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals
Abstract Our research group has recently found that radiation-induced airborne stress signals can be used for communication among Caenorhabditis elegans (C. elegans). This paper addresses the question of whether heat stress can also induce the emission of airborne stress signals to alert neighboring...
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| Format: | Article |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26554-8 |
| _version_ | 1797864956829368320 |
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| author | Liangwen Chen Yun Wang Xiuhong Zhou Ting Wang Huimin Zhan Fei Wu Haolan Li Po Bian Zhongwen Xie |
| author_facet | Liangwen Chen Yun Wang Xiuhong Zhou Ting Wang Huimin Zhan Fei Wu Haolan Li Po Bian Zhongwen Xie |
| author_sort | Liangwen Chen |
| collection | DOAJ |
| description | Abstract Our research group has recently found that radiation-induced airborne stress signals can be used for communication among Caenorhabditis elegans (C. elegans). This paper addresses the question of whether heat stress can also induce the emission of airborne stress signals to alert neighboring C. elegans and elicit their subsequent stress response. Here, we report that heat-stressed C. elegans produces volatile stress signals that trigger an increase in radiation resistance in neighboring unheated C. elegans. When several loss-of-function mutations affecting thermosensory neuron (AFD), heat shock factor-1, HSP-4, and small heat-shock proteins were used to test heat-stressed C. elegans, we found that the production of volatile stress signals was blocked, demonstrating that the heat shock response and ER pathway are involved in controlling the production of volatile stress signals. Our data further indicated that mutations affecting the DNA damage response (DDR) also inhibited the increase in radiation resistance in neighboring unheated C. elegans that might have received volatile stress signals, indicating that the DDR might contribute to radioadaptive responses induction by volatile stress signals. In addition, the regulatory pattern of signal production and action was preliminarily clarified. Together, the results of this study demonstrated that heat-stressed nematodes communicate with unheated nematodes via volatile stress signals. |
| first_indexed | 2024-04-09T23:01:10Z |
| format | Article |
| id | doaj.art-d1586c35091f4c429b01c3acb8e6a5ec |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:01:10Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d1586c35091f4c429b01c3acb8e6a5ec2023-03-22T11:00:26ZengNature PortfolioScientific Reports2045-23222023-02-0113111010.1038/s41598-022-26554-8Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signalsLiangwen Chen0Yun Wang1Xiuhong Zhou2Ting Wang3Huimin Zhan4Fei Wu5Haolan Li6Po Bian7Zhongwen Xie8State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural UniversityKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Bioengineering, Huainan Normal UniversityState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural UniversityKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of SciencesKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Bioengineering, Huainan Normal UniversityKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Bioengineering, Huainan Normal UniversityKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Bioengineering, Huainan Normal UniversityKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of SciencesState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural UniversityAbstract Our research group has recently found that radiation-induced airborne stress signals can be used for communication among Caenorhabditis elegans (C. elegans). This paper addresses the question of whether heat stress can also induce the emission of airborne stress signals to alert neighboring C. elegans and elicit their subsequent stress response. Here, we report that heat-stressed C. elegans produces volatile stress signals that trigger an increase in radiation resistance in neighboring unheated C. elegans. When several loss-of-function mutations affecting thermosensory neuron (AFD), heat shock factor-1, HSP-4, and small heat-shock proteins were used to test heat-stressed C. elegans, we found that the production of volatile stress signals was blocked, demonstrating that the heat shock response and ER pathway are involved in controlling the production of volatile stress signals. Our data further indicated that mutations affecting the DNA damage response (DDR) also inhibited the increase in radiation resistance in neighboring unheated C. elegans that might have received volatile stress signals, indicating that the DDR might contribute to radioadaptive responses induction by volatile stress signals. In addition, the regulatory pattern of signal production and action was preliminarily clarified. Together, the results of this study demonstrated that heat-stressed nematodes communicate with unheated nematodes via volatile stress signals.https://doi.org/10.1038/s41598-022-26554-8 |
| spellingShingle | Liangwen Chen Yun Wang Xiuhong Zhou Ting Wang Huimin Zhan Fei Wu Haolan Li Po Bian Zhongwen Xie Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals Scientific Reports |
| title | Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals |
| title_full | Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals |
| title_fullStr | Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals |
| title_full_unstemmed | Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals |
| title_short | Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals |
| title_sort | investigation into the communication between unheated and heat stressed caenorhabditis elegans via volatile stress signals |
| url | https://doi.org/10.1038/s41598-022-26554-8 |
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