DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage
DNA damage-inducing therapies are of tremendous value for cancer treatment and function by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular proliferation. Of central importance in the cellular response to therapy-induced DNA damage is the DNA damage response (DDR...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/8/2098 |
| _version_ | 1797561101878034432 |
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| author | Thom G. A. Reuvers Roland Kanaar Julie Nonnekens |
| author_facet | Thom G. A. Reuvers Roland Kanaar Julie Nonnekens |
| author_sort | Thom G. A. Reuvers |
| collection | DOAJ |
| description | DNA damage-inducing therapies are of tremendous value for cancer treatment and function by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular proliferation. Of central importance in the cellular response to therapy-induced DNA damage is the DNA damage response (DDR), a protein network guiding both DNA damage repair and the induction of cancer-eradicating mechanisms such as apoptosis. A detailed understanding of DNA damage induction and the DDR has greatly improved our knowledge of the classical DNA damage-inducing therapies, radiotherapy and cytotoxic chemotherapy, and has paved the way for rational improvement of these treatments. Moreover, compounds targeting specific DDR proteins, selectively impairing DNA damage repair in cancer cells, form a promising novel therapy class that is now entering the clinic. In this review, we give an overview of the current state and ongoing developments, and discuss potential avenues for improvement for DNA damage-inducing therapies, with a central focus on the role of the DDR in therapy response, toxicity and resistance. Furthermore, we describe the relevance of using combination regimens containing DNA damage-inducing therapies and how they can be utilized to potentiate other anticancer strategies such as immunotherapy. |
| first_indexed | 2024-03-10T18:09:32Z |
| format | Article |
| id | doaj.art-d1593cd8c9b340beb0cc6c33173b4e8b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:09:32Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d1593cd8c9b340beb0cc6c33173b4e8b2023-11-20T08:16:03ZengMDPI AGCancers2072-66942020-07-01128209810.3390/cancers12082098DNA Damage-Inducing Anticancer Therapies: From Global to Precision DamageThom G. A. Reuvers0Roland Kanaar1Julie Nonnekens2Department of Molecular Genetics, Erasmus MC, Dr. Molenwaterplein 40, 3015 GD Rotterdam, The NetherlandsDepartment of Molecular Genetics, Erasmus MC, Dr. Molenwaterplein 40, 3015 GD Rotterdam, The NetherlandsDepartment of Molecular Genetics, Erasmus MC, Dr. Molenwaterplein 40, 3015 GD Rotterdam, The NetherlandsDNA damage-inducing therapies are of tremendous value for cancer treatment and function by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular proliferation. Of central importance in the cellular response to therapy-induced DNA damage is the DNA damage response (DDR), a protein network guiding both DNA damage repair and the induction of cancer-eradicating mechanisms such as apoptosis. A detailed understanding of DNA damage induction and the DDR has greatly improved our knowledge of the classical DNA damage-inducing therapies, radiotherapy and cytotoxic chemotherapy, and has paved the way for rational improvement of these treatments. Moreover, compounds targeting specific DDR proteins, selectively impairing DNA damage repair in cancer cells, form a promising novel therapy class that is now entering the clinic. In this review, we give an overview of the current state and ongoing developments, and discuss potential avenues for improvement for DNA damage-inducing therapies, with a central focus on the role of the DDR in therapy response, toxicity and resistance. Furthermore, we describe the relevance of using combination regimens containing DNA damage-inducing therapies and how they can be utilized to potentiate other anticancer strategies such as immunotherapy.https://www.mdpi.com/2072-6694/12/8/2098DNA damage-inducing therapiescancer therapyDNA damage responseDNA repairradiotherapycytotoxic chemotherapy |
| spellingShingle | Thom G. A. Reuvers Roland Kanaar Julie Nonnekens DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage Cancers DNA damage-inducing therapies cancer therapy DNA damage response DNA repair radiotherapy cytotoxic chemotherapy |
| title | DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage |
| title_full | DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage |
| title_fullStr | DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage |
| title_full_unstemmed | DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage |
| title_short | DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage |
| title_sort | dna damage inducing anticancer therapies from global to precision damage |
| topic | DNA damage-inducing therapies cancer therapy DNA damage response DNA repair radiotherapy cytotoxic chemotherapy |
| url | https://www.mdpi.com/2072-6694/12/8/2098 |
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