Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation
The purpose of the current study was to assess the prevalence of cyst formation at the brain-tumor interface in olfactory neuroblastoma. We used the UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify the largest patient cohort reported to date with imaging...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/3/614 |
| _version_ | 1797472028008120320 |
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| author | Rebecca A. Dumont Miguel Fernando Palma Diaz William Hsu Ali R. Sepahdari |
| author_facet | Rebecca A. Dumont Miguel Fernando Palma Diaz William Hsu Ali R. Sepahdari |
| author_sort | Rebecca A. Dumont |
| collection | DOAJ |
| description | The purpose of the current study was to assess the prevalence of cyst formation at the brain-tumor interface in olfactory neuroblastoma. We used the UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify the largest patient cohort reported to date with imaging and pathology data. Eighteen of thirty-one patients (58.1%) had evidence of intracranial extension on MRI, while four (22.0%) demonstrated cyst formation at the brain–tumor interface. The extent of intracranial extension was by far the strongest predictor for intracranial cyst formation, regardless of Hyams tumor grade, using a binary logistics regression model (<i>p</i> = 0.002) and ROC curve analysis (AUC 94.6%). Cyst formation at the brain-tumor interface was an uncommon imaging finding, and tends to occur with a larger component of intracranial tumor extension. |
| first_indexed | 2024-03-09T19:57:23Z |
| format | Article |
| id | doaj.art-d15a24833a1a40cf8090dc956cb70a39 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:57:23Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d15a24833a1a40cf8090dc956cb70a392023-11-24T00:54:50ZengMDPI AGDiagnostics2075-44182022-03-0112361410.3390/diagnostics12030614Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst FormationRebecca A. Dumont0Miguel Fernando Palma Diaz1William Hsu2Ali R. Sepahdari3Neuroradiology Section, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USADepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USAMedical & Imaging Informatics, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USANeuroradiology Section, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USAThe purpose of the current study was to assess the prevalence of cyst formation at the brain-tumor interface in olfactory neuroblastoma. We used the UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify the largest patient cohort reported to date with imaging and pathology data. Eighteen of thirty-one patients (58.1%) had evidence of intracranial extension on MRI, while four (22.0%) demonstrated cyst formation at the brain–tumor interface. The extent of intracranial extension was by far the strongest predictor for intracranial cyst formation, regardless of Hyams tumor grade, using a binary logistics regression model (<i>p</i> = 0.002) and ROC curve analysis (AUC 94.6%). Cyst formation at the brain-tumor interface was an uncommon imaging finding, and tends to occur with a larger component of intracranial tumor extension.https://www.mdpi.com/2075-4418/12/3/614olfactory neuroblastomaesthesioneuroblastomaMRIradiology–pathology correlation |
| spellingShingle | Rebecca A. Dumont Miguel Fernando Palma Diaz William Hsu Ali R. Sepahdari Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation Diagnostics olfactory neuroblastoma esthesioneuroblastoma MRI radiology–pathology correlation |
| title | Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation |
| title_full | Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation |
| title_fullStr | Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation |
| title_full_unstemmed | Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation |
| title_short | Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation |
| title_sort | olfactory neuroblastoma re evaluating the paradigm of intracranial extension and cyst formation |
| topic | olfactory neuroblastoma esthesioneuroblastoma MRI radiology–pathology correlation |
| url | https://www.mdpi.com/2075-4418/12/3/614 |
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