Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand
Distal cholangiocarcinoma (dCCA) is a rare type of CCA in Asia, even in Opisthorchis viverrini-prevalent Northeastern Thailand. The clinical ambiguity and imprecision of diagnosis surrounding this malignancy result in high mortality due often to advanced/metastatic disease on presentation. We aim to...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.816028/full |
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| author | Waritta Kunprom Waritta Kunprom Waritta Kunprom Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Sakkarn Sangkhamanon Sakkarn Sangkhamanon Sakkarn Sangkhamanon Piyapharom Intarawichian Piyapharom Intarawichian Piyapharom Intarawichian Walailak Bamrungkit Walailak Bamrungkit Walailak Bamrungkit Malinee Thanee Malinee Thanee Malinee Thanee Piya Prajumwongs Piya Prajumwongs Piya Prajumwongs Watcharin Loilome Watcharin Loilome Watcharin Loilome Narong Khuntikeo Narong Khuntikeo Narong Khuntikeo Attapol Titapun Attapol Titapun Attapol Titapun Apiwat Jareanrat Apiwat Jareanrat Apiwat Jareanrat Vasin Thanasukarn Vasin Thanasukarn Vasin Thanasukarn Tharatip Srisuk Tharatip Srisuk Tharatip Srisuk Vor Luvira Vor Luvira Vor Luvira Kulyada Eurboonyanun Kulyada Eurboonyanun Kulyada Eurboonyanun Julaluck Promsorn Julaluck Promsorn Julaluck Promsorn Supinda Koonmee Supinda Koonmee Supinda Koonmee |
| author_facet | Waritta Kunprom Waritta Kunprom Waritta Kunprom Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Sakkarn Sangkhamanon Sakkarn Sangkhamanon Sakkarn Sangkhamanon Piyapharom Intarawichian Piyapharom Intarawichian Piyapharom Intarawichian Walailak Bamrungkit Walailak Bamrungkit Walailak Bamrungkit Malinee Thanee Malinee Thanee Malinee Thanee Piya Prajumwongs Piya Prajumwongs Piya Prajumwongs Watcharin Loilome Watcharin Loilome Watcharin Loilome Narong Khuntikeo Narong Khuntikeo Narong Khuntikeo Attapol Titapun Attapol Titapun Attapol Titapun Apiwat Jareanrat Apiwat Jareanrat Apiwat Jareanrat Vasin Thanasukarn Vasin Thanasukarn Vasin Thanasukarn Tharatip Srisuk Tharatip Srisuk Tharatip Srisuk Vor Luvira Vor Luvira Vor Luvira Kulyada Eurboonyanun Kulyada Eurboonyanun Kulyada Eurboonyanun Julaluck Promsorn Julaluck Promsorn Julaluck Promsorn Supinda Koonmee Supinda Koonmee Supinda Koonmee |
| author_sort | Waritta Kunprom |
| collection | DOAJ |
| description | Distal cholangiocarcinoma (dCCA) is a rare type of CCA in Asia, even in Opisthorchis viverrini-prevalent Northeastern Thailand. The clinical ambiguity and imprecision of diagnosis surrounding this malignancy result in high mortality due often to advanced/metastatic disease on presentation. We aim to identify a prognostic factor that can improve the performance stratification and influence the outcome of dCCA patients after curative resection. A total of 79 patients who underwent curative-intended surgery for dCCA was enrolled. Possible risk factors for survival were analyzed with log-rank test, and independent factors with Cox regression model. dCCA patients were staged and classified according to the 8th edition the American Joint Committee on Cancer (AJCC) Staging Manual. Results were then compared with the revised classification employing the prognostic factor identified from multivariate analysis. Multivariate analysis revealed that growth pattern (p < 0.01) and distant metastasis (p = 0.012) were independent factors. Growth patterns comprise intraductal (ID), periductal infiltrating (PI), mass-forming (MF), and mixed types. When dCCA patients were grouped into those having good and poor outcomes (with and without ID components, respectively). The survival outcomes significantly differed among patients with and without ID components, which was better than with the 8th AJCC staging system in our cohort. Furthermore, Chi-square test showed that patterns without ID components (PI, MF, PI + MF) correlated with lymph node and distant metastasis. Therefore, classification of dCCA patients after curative-intended surgical resection based on growth pattern provides additional beneficial information for the prediction of survival in dCCA patients. |
| first_indexed | 2024-12-12T03:11:12Z |
| format | Article |
| id | doaj.art-d15b0756bdac4c70879da60f0f2ce174 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-12T03:11:12Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-d15b0756bdac4c70879da60f0f2ce1742022-12-22T00:40:23ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-05-011010.3389/fpubh.2022.816028816028Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in ThailandWaritta Kunprom0Waritta Kunprom1Waritta Kunprom2Chaiwat Aphivatanasiri3Chaiwat Aphivatanasiri4Chaiwat Aphivatanasiri5Prakasit Sa-ngiamwibool6Prakasit Sa-ngiamwibool7Prakasit Sa-ngiamwibool8Sakkarn Sangkhamanon9Sakkarn Sangkhamanon10Sakkarn Sangkhamanon11Piyapharom Intarawichian12Piyapharom Intarawichian13Piyapharom Intarawichian14Walailak Bamrungkit15Walailak Bamrungkit16Walailak Bamrungkit17Malinee Thanee18Malinee Thanee19Malinee Thanee20Piya Prajumwongs21Piya Prajumwongs22Piya Prajumwongs23Watcharin Loilome24Watcharin Loilome25Watcharin Loilome26Narong Khuntikeo27Narong Khuntikeo28Narong Khuntikeo29Attapol Titapun30Attapol Titapun31Attapol Titapun32Apiwat Jareanrat33Apiwat Jareanrat34Apiwat Jareanrat35Vasin Thanasukarn36Vasin Thanasukarn37Vasin Thanasukarn38Tharatip Srisuk39Tharatip Srisuk40Tharatip Srisuk41Vor Luvira42Vor Luvira43Vor Luvira44Kulyada Eurboonyanun45Kulyada Eurboonyanun46Kulyada Eurboonyanun47Julaluck Promsorn48Julaluck Promsorn49Julaluck Promsorn50Supinda Koonmee51Supinda Koonmee52Supinda Koonmee53Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDistal cholangiocarcinoma (dCCA) is a rare type of CCA in Asia, even in Opisthorchis viverrini-prevalent Northeastern Thailand. The clinical ambiguity and imprecision of diagnosis surrounding this malignancy result in high mortality due often to advanced/metastatic disease on presentation. We aim to identify a prognostic factor that can improve the performance stratification and influence the outcome of dCCA patients after curative resection. A total of 79 patients who underwent curative-intended surgery for dCCA was enrolled. Possible risk factors for survival were analyzed with log-rank test, and independent factors with Cox regression model. dCCA patients were staged and classified according to the 8th edition the American Joint Committee on Cancer (AJCC) Staging Manual. Results were then compared with the revised classification employing the prognostic factor identified from multivariate analysis. Multivariate analysis revealed that growth pattern (p < 0.01) and distant metastasis (p = 0.012) were independent factors. Growth patterns comprise intraductal (ID), periductal infiltrating (PI), mass-forming (MF), and mixed types. When dCCA patients were grouped into those having good and poor outcomes (with and without ID components, respectively). The survival outcomes significantly differed among patients with and without ID components, which was better than with the 8th AJCC staging system in our cohort. Furthermore, Chi-square test showed that patterns without ID components (PI, MF, PI + MF) correlated with lymph node and distant metastasis. Therefore, classification of dCCA patients after curative-intended surgical resection based on growth pattern provides additional beneficial information for the prediction of survival in dCCA patients.https://www.frontiersin.org/articles/10.3389/fpubh.2022.816028/fulldistal cholangiocarcinoma8th AJCC staging systemgrowth patternclassificationprognosis |
| spellingShingle | Waritta Kunprom Waritta Kunprom Waritta Kunprom Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Sakkarn Sangkhamanon Sakkarn Sangkhamanon Sakkarn Sangkhamanon Piyapharom Intarawichian Piyapharom Intarawichian Piyapharom Intarawichian Walailak Bamrungkit Walailak Bamrungkit Walailak Bamrungkit Malinee Thanee Malinee Thanee Malinee Thanee Piya Prajumwongs Piya Prajumwongs Piya Prajumwongs Watcharin Loilome Watcharin Loilome Watcharin Loilome Narong Khuntikeo Narong Khuntikeo Narong Khuntikeo Attapol Titapun Attapol Titapun Attapol Titapun Apiwat Jareanrat Apiwat Jareanrat Apiwat Jareanrat Vasin Thanasukarn Vasin Thanasukarn Vasin Thanasukarn Tharatip Srisuk Tharatip Srisuk Tharatip Srisuk Vor Luvira Vor Luvira Vor Luvira Kulyada Eurboonyanun Kulyada Eurboonyanun Kulyada Eurboonyanun Julaluck Promsorn Julaluck Promsorn Julaluck Promsorn Supinda Koonmee Supinda Koonmee Supinda Koonmee Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand Frontiers in Public Health distal cholangiocarcinoma 8th AJCC staging system growth pattern classification prognosis |
| title | Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand |
| title_full | Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand |
| title_fullStr | Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand |
| title_full_unstemmed | Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand |
| title_short | Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand |
| title_sort | prognostic significance of growth pattern in predicting outcome of opisthorchis viverrini associated distal cholangiocarcinoma in thailand |
| topic | distal cholangiocarcinoma 8th AJCC staging system growth pattern classification prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.816028/full |
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