Optimality, cost minimization and the design of arterial networks
The arterial circulation acts as a network to deliver nutrients and oxygen to cells. The design of the cardiovascular system is subject to a variety of constraints and costs. It has been postulated that the design of the arterial network might be understood in terms of the need to minimize competing...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2015-02-01
|
| Series: | Artery Research |
| Subjects: | |
| Online Access: | https://www.atlantis-press.com/article/125925201/view |
| _version_ | 1818006220307431424 |
|---|---|
| author | Alun D. Hughes |
| author_facet | Alun D. Hughes |
| author_sort | Alun D. Hughes |
| collection | DOAJ |
| description | The arterial circulation acts as a network to deliver nutrients and oxygen to cells. The design of the cardiovascular system is subject to a variety of constraints and costs. It has been postulated that the design of the arterial network might be understood in terms of the need to minimize competing ‘costs’ within the context of physical or material limits to the system. These designs can also be envisaged as being subservient to space filling or fractal considerations. The signalling mechanisms underlying these designs remain to be fully characterized although shear stress, wall tensile stress and metabolic stimuli are likely candidates. I will also review evidence that deviations from a minimal cost condition or optimal design may provide both a measure of disease severity and insights into the underlying disease mechanism. |
| first_indexed | 2024-04-14T04:57:21Z |
| format | Article |
| id | doaj.art-d15b60c0c81c497c9827b7acb661ab56 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-14T04:57:21Z |
| publishDate | 2015-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-d15b60c0c81c497c9827b7acb661ab562022-12-22T02:11:07ZengBMCArtery Research1876-44012015-02-011010.1016/j.artres.2015.01.001Optimality, cost minimization and the design of arterial networksAlun D. HughesThe arterial circulation acts as a network to deliver nutrients and oxygen to cells. The design of the cardiovascular system is subject to a variety of constraints and costs. It has been postulated that the design of the arterial network might be understood in terms of the need to minimize competing ‘costs’ within the context of physical or material limits to the system. These designs can also be envisaged as being subservient to space filling or fractal considerations. The signalling mechanisms underlying these designs remain to be fully characterized although shear stress, wall tensile stress and metabolic stimuli are likely candidates. I will also review evidence that deviations from a minimal cost condition or optimal design may provide both a measure of disease severity and insights into the underlying disease mechanism.https://www.atlantis-press.com/article/125925201/viewCirculationDesignOptimalityShear stress |
| spellingShingle | Alun D. Hughes Optimality, cost minimization and the design of arterial networks Artery Research Circulation Design Optimality Shear stress |
| title | Optimality, cost minimization and the design of arterial networks |
| title_full | Optimality, cost minimization and the design of arterial networks |
| title_fullStr | Optimality, cost minimization and the design of arterial networks |
| title_full_unstemmed | Optimality, cost minimization and the design of arterial networks |
| title_short | Optimality, cost minimization and the design of arterial networks |
| title_sort | optimality cost minimization and the design of arterial networks |
| topic | Circulation Design Optimality Shear stress |
| url | https://www.atlantis-press.com/article/125925201/view |
| work_keys_str_mv | AT alundhughes optimalitycostminimizationandthedesignofarterialnetworks |