Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells
Abstract Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previously, autophagy was described in the context of cell activity and behavior, but litt...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-018-1060-5 |
| _version_ | 1819076893829234688 |
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| author | Mehdi Hassanpour Aysa Rezabakhsh Masoud Pezeshkian Reza Rahbarghazi Mohammad Nouri |
| author_facet | Mehdi Hassanpour Aysa Rezabakhsh Masoud Pezeshkian Reza Rahbarghazi Mohammad Nouri |
| author_sort | Mehdi Hassanpour |
| collection | DOAJ |
| description | Abstract Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previously, autophagy was described in the context of cell activity and behavior, but little knowledge exists related to the role of autophagy in endothelial cells, progenitors, and stem cells biology from different tissues. Angiogenic behavior of endothelial lineage and various stem cells are touted as an inevitable feature in the restoration of different damaged tissues and organs. This capacity was found to be dictated by autophagy signaling pathway. This review article highlights the fundamental role of cell autophagic response in endothelial cells function, stem cells dynamic, and differentiation rate. It seems that elucidation of the mechanisms related to pro- and/or anti-angiogenic potential of autophagy inside endothelial cells and stem cells could help us to modulate stem cell therapeutic feature post-transplantation. |
| first_indexed | 2024-12-21T18:48:33Z |
| format | Article |
| id | doaj.art-d15cd8bfbfa9487aabbb39f8153f9093 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-21T18:48:33Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-d15cd8bfbfa9487aabbb39f8153f90932022-12-21T18:53:50ZengBMCStem Cell Research & Therapy1757-65122018-11-019111610.1186/s13287-018-1060-5Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cellsMehdi Hassanpour0Aysa Rezabakhsh1Masoud Pezeshkian2Reza Rahbarghazi3Mohammad Nouri4Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical SciencesEmergency Medicine Research Team, Tabriz University of Medical SciencesDepartment of Applied Drug Research, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesDepartment of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical SciencesAbstract Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previously, autophagy was described in the context of cell activity and behavior, but little knowledge exists related to the role of autophagy in endothelial cells, progenitors, and stem cells biology from different tissues. Angiogenic behavior of endothelial lineage and various stem cells are touted as an inevitable feature in the restoration of different damaged tissues and organs. This capacity was found to be dictated by autophagy signaling pathway. This review article highlights the fundamental role of cell autophagic response in endothelial cells function, stem cells dynamic, and differentiation rate. It seems that elucidation of the mechanisms related to pro- and/or anti-angiogenic potential of autophagy inside endothelial cells and stem cells could help us to modulate stem cell therapeutic feature post-transplantation.http://link.springer.com/article/10.1186/s13287-018-1060-5Stem cellAutophagyAngiogenesisDifferentiationFunctional maturation |
| spellingShingle | Mehdi Hassanpour Aysa Rezabakhsh Masoud Pezeshkian Reza Rahbarghazi Mohammad Nouri Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells Stem Cell Research & Therapy Stem cell Autophagy Angiogenesis Differentiation Functional maturation |
| title | Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells |
| title_full | Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells |
| title_fullStr | Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells |
| title_full_unstemmed | Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells |
| title_short | Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells |
| title_sort | distinct role of autophagy on angiogenesis highlights on the effect of autophagy in endothelial lineage and progenitor cells |
| topic | Stem cell Autophagy Angiogenesis Differentiation Functional maturation |
| url | http://link.springer.com/article/10.1186/s13287-018-1060-5 |
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