Relationship of Lysosomal Storage Diseases (LSD) with Autophagy
Lysosomes are organelles that degrade damaged components or structures that have completed their functions and have roles in the last step of the autophagy pathway. Damage of the autophagy-lysosome pathway can cause vital problems for the cell. Lysosomal storage diseases (LSD) are one of the most co...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2022-10-01
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| Series: | Van Tıp Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-95776 |
| _version_ | 1827608621073039360 |
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| author | Seda Keskin İsmail Mert Alkaç Burcu Çerçi |
| author_facet | Seda Keskin İsmail Mert Alkaç Burcu Çerçi |
| author_sort | Seda Keskin |
| collection | DOAJ |
| description | Lysosomes are organelles that degrade damaged components or structures that have completed their functions and have roles in the last step of the autophagy pathway. Damage of the autophagy-lysosome pathway can cause vital problems for the cell. Lysosomal storage diseases (LSD) are one of the most common human genetic disorder caused by gene mutations. Up to now, more than 70 LSD were identified. LSD is mainly caused by functional disorders of enzymes in lysosomes or proteins associated with lysosomes. These disorders lead to the accumulation of undigested macromolecules in cells LSD can cause many systemic damages mainly in the nervous system, skeletal system, and reticuloendothelial system especially at early stages of the disease. Modulation and reactivation of autophagy is accepted as a new therapeutic approach for LSD. In this review, the general mechanisms of the relationship between lysosomal storage diseases and autophagy were evaluated together with the treatment approaches. |
| first_indexed | 2024-03-09T07:17:08Z |
| format | Article |
| id | doaj.art-d15d22d997204b0c805889e908909de6 |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T07:17:08Z |
| publishDate | 2022-10-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-d15d22d997204b0c805889e908909de62023-12-03T08:29:23ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512022-10-0129444545310.5505/vtd.2022.95776VTD-95776Relationship of Lysosomal Storage Diseases (LSD) with AutophagySeda Keskin0İsmail Mert Alkaç1Burcu Çerçi2Van Yüzüncü Yıl University, Faculty of Medicine Department of Medical Histology and Embryology, VanDumlupınar University, Faculty of Engineering, Department of Materials Science Engineering, Kütahyaİzmir Katip Çelebi University, Faculty of Medicine, Department of Medical Biology and Genetics, İzmirLysosomes are organelles that degrade damaged components or structures that have completed their functions and have roles in the last step of the autophagy pathway. Damage of the autophagy-lysosome pathway can cause vital problems for the cell. Lysosomal storage diseases (LSD) are one of the most common human genetic disorder caused by gene mutations. Up to now, more than 70 LSD were identified. LSD is mainly caused by functional disorders of enzymes in lysosomes or proteins associated with lysosomes. These disorders lead to the accumulation of undigested macromolecules in cells LSD can cause many systemic damages mainly in the nervous system, skeletal system, and reticuloendothelial system especially at early stages of the disease. Modulation and reactivation of autophagy is accepted as a new therapeutic approach for LSD. In this review, the general mechanisms of the relationship between lysosomal storage diseases and autophagy were evaluated together with the treatment approaches.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-95776autophagylysosomal storage diseaseendosomeprotein function loss |
| spellingShingle | Seda Keskin İsmail Mert Alkaç Burcu Çerçi Relationship of Lysosomal Storage Diseases (LSD) with Autophagy Van Tıp Dergisi autophagy lysosomal storage disease endosome protein function loss |
| title | Relationship of Lysosomal Storage Diseases (LSD) with Autophagy |
| title_full | Relationship of Lysosomal Storage Diseases (LSD) with Autophagy |
| title_fullStr | Relationship of Lysosomal Storage Diseases (LSD) with Autophagy |
| title_full_unstemmed | Relationship of Lysosomal Storage Diseases (LSD) with Autophagy |
| title_short | Relationship of Lysosomal Storage Diseases (LSD) with Autophagy |
| title_sort | relationship of lysosomal storage diseases lsd with autophagy |
| topic | autophagy lysosomal storage disease endosome protein function loss |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-95776 |
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