Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps
Chitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical cross-linking. A much more friendly approach to deliver drugs in a controlled manner is represented by polyelectrolyte complexes (PECs) physically stabilized by spontaneous interactions between CS and natural or synthe...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/4/240 |
| _version_ | 1797434661156159488 |
|---|---|
| author | Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita |
| author_facet | Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita |
| author_sort | Ecaterina Stela Dragan |
| collection | DOAJ |
| description | Chitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical cross-linking. A much more friendly approach to deliver drugs in a controlled manner is represented by polyelectrolyte complexes (PECs) physically stabilized by spontaneous interactions between CS and natural or synthetic biocompatible polyanions. PECs with tunable structures, morphologies, and mechanical properties were fabricated in this paper by an innovative and sustainable strategy. Carboxymethyl cellulose (CMC) or poly(2-acrylamido-2-methylpropanesulfonate sodium salt) were used as aqueous solutions, while CS microparticles were evenly dispersed in the polyanion solution, at pH 6.5, where CS was not soluble. Cryostructuration of the dispersion in two steps (5 min at −196 °C, and 24 h at −18 °C), and freeze-drying at −55 °C, 48 h, conducted to pre-PEC cryogels. Next step was rearrangement of complementary polyions and the complex formation inside the pore walls of cryogels by exposure of the pre-PECs at a source of H<sup>+</sup>. PEC cryogels with impressive elasticity and toughness were engineered in this study by multiple-cryostructuration steps using CMC as polyanion with a molar mass of 250 kDa and an optimum concentration of polyanion and polycation. The performances of PEC cryogels in sustained delivery of anti-inflammatory drugs such as curcumin were demonstrated. |
| first_indexed | 2024-03-09T10:36:42Z |
| format | Article |
| id | doaj.art-d15d90e45abd4e85b31cd68e1ec3687c |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T10:36:42Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-d15d90e45abd4e85b31cd68e1ec3687c2023-12-01T20:56:09ZengMDPI AGGels2310-28612022-04-018424010.3390/gels8040240Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration StepsEcaterina Stela Dragan0Maria Valentina Dinu1Claudiu Augustin Ghiorghita2Department of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaDepartment of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaDepartment of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaChitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical cross-linking. A much more friendly approach to deliver drugs in a controlled manner is represented by polyelectrolyte complexes (PECs) physically stabilized by spontaneous interactions between CS and natural or synthetic biocompatible polyanions. PECs with tunable structures, morphologies, and mechanical properties were fabricated in this paper by an innovative and sustainable strategy. Carboxymethyl cellulose (CMC) or poly(2-acrylamido-2-methylpropanesulfonate sodium salt) were used as aqueous solutions, while CS microparticles were evenly dispersed in the polyanion solution, at pH 6.5, where CS was not soluble. Cryostructuration of the dispersion in two steps (5 min at −196 °C, and 24 h at −18 °C), and freeze-drying at −55 °C, 48 h, conducted to pre-PEC cryogels. Next step was rearrangement of complementary polyions and the complex formation inside the pore walls of cryogels by exposure of the pre-PECs at a source of H<sup>+</sup>. PEC cryogels with impressive elasticity and toughness were engineered in this study by multiple-cryostructuration steps using CMC as polyanion with a molar mass of 250 kDa and an optimum concentration of polyanion and polycation. The performances of PEC cryogels in sustained delivery of anti-inflammatory drugs such as curcumin were demonstrated.https://www.mdpi.com/2310-2861/8/4/240carboxymethyl cellulosechitosanpoly(2-acrylamido-2-methyl-propansulfonic acid)polyelectrolyte complexcurcumindrug delivery |
| spellingShingle | Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps Gels carboxymethyl cellulose chitosan poly(2-acrylamido-2-methyl-propansulfonic acid) polyelectrolyte complex curcumin drug delivery |
| title | Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps |
| title_full | Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps |
| title_fullStr | Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps |
| title_full_unstemmed | Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps |
| title_short | Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps |
| title_sort | chitosan based polyelectrolyte complex cryogels with elasticity toughness and delivery of curcumin engineered by polyions pair and cryostructuration steps |
| topic | carboxymethyl cellulose chitosan poly(2-acrylamido-2-methyl-propansulfonic acid) polyelectrolyte complex curcumin drug delivery |
| url | https://www.mdpi.com/2310-2861/8/4/240 |
| work_keys_str_mv | AT ecaterinasteladragan chitosanbasedpolyelectrolytecomplexcryogelswithelasticitytoughnessanddeliveryofcurcuminengineeredbypolyionspairandcryostructurationsteps AT mariavalentinadinu chitosanbasedpolyelectrolytecomplexcryogelswithelasticitytoughnessanddeliveryofcurcuminengineeredbypolyionspairandcryostructurationsteps AT claudiuaugustinghiorghita chitosanbasedpolyelectrolytecomplexcryogelswithelasticitytoughnessanddeliveryofcurcuminengineeredbypolyionspairandcryostructurationsteps |