Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

KCNQ2/3 channels, ubiquitously expressed neuronal potassium channels, have emerged as indispensable regulators of brain network activity. Despite their critical role in brain homeostasis, the mechanisms by which KCNQ2/3 dysfunction lead to hypersychrony are not fully known. Here, we show that deleti...

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Bibliographic Details
Main Authors: Heun Soh, Suhyeorn Park, Kali Ryan, Kristen Springer, Atul Maheshwari, Anastasios V Tzingounis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
potassium channels
KCNQ2
KCNQ3
interneurons
epilepsy
seizure
Online Access:https://elifesciences.org/articles/38617

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