How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours
Viruses efficiently transfer and express their genes in host cells and evolve to evade the host’s defense responses. These properties render them highly attractive for use as gene delivery vectors in vaccines, gene, and immunotherapies. Among the viruses used as gene delivery vectors, the macaque po...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01160/full |
| _version_ | 1817994769508335616 |
|---|---|
| author | Miguel G. Toscano Peter de Haan |
| author_facet | Miguel G. Toscano Peter de Haan |
| author_sort | Miguel G. Toscano |
| collection | DOAJ |
| description | Viruses efficiently transfer and express their genes in host cells and evolve to evade the host’s defense responses. These properties render them highly attractive for use as gene delivery vectors in vaccines, gene, and immunotherapies. Among the viruses used as gene delivery vectors, the macaque polyomavirus Simian Virus 40 (SV40) is unique in its capacity to evade intracellular antiviral defense responses upon cell entry. We here describe the unique way by which SV40 particles deliver their genomes in the nucleus of permissive cells and how they prevent presentation of viral antigens to the host’s immune system. The non-immunogenicity in its natural host is not only of benefit to the virus but also to us in developing effective SV40 vector-based treatments for today’s major human diseases. |
| first_indexed | 2024-04-14T01:56:37Z |
| format | Article |
| id | doaj.art-d16032fe67804711998b62aa64020570 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T01:56:37Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d16032fe67804711998b62aa640205702022-12-22T02:19:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01160358748How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and OursMiguel G. Toscano0Peter de Haan1Amarna Therapeutics SL, Sevilla, SpainAmarna Therapeutics BV, Leiden, NetherlandsViruses efficiently transfer and express their genes in host cells and evolve to evade the host’s defense responses. These properties render them highly attractive for use as gene delivery vectors in vaccines, gene, and immunotherapies. Among the viruses used as gene delivery vectors, the macaque polyomavirus Simian Virus 40 (SV40) is unique in its capacity to evade intracellular antiviral defense responses upon cell entry. We here describe the unique way by which SV40 particles deliver their genomes in the nucleus of permissive cells and how they prevent presentation of viral antigens to the host’s immune system. The non-immunogenicity in its natural host is not only of benefit to the virus but also to us in developing effective SV40 vector-based treatments for today’s major human diseases.https://www.frontiersin.org/article/10.3389/fimmu.2018.01160/fullSimian Virus 40polyomavirusimmune evasionviral vectornon-immunogenicityimmune tolerance |
| spellingShingle | Miguel G. Toscano Peter de Haan How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours Frontiers in Immunology Simian Virus 40 polyomavirus immune evasion viral vector non-immunogenicity immune tolerance |
| title | How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours |
| title_full | How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours |
| title_fullStr | How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours |
| title_full_unstemmed | How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours |
| title_short | How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours |
| title_sort | how simian virus 40 hijacks the intracellular protein trafficking pathway to its own benefit and ours |
| topic | Simian Virus 40 polyomavirus immune evasion viral vector non-immunogenicity immune tolerance |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01160/full |
| work_keys_str_mv | AT miguelgtoscano howsimianvirus40hijackstheintracellularproteintraffickingpathwaytoitsownbenefitandours AT peterdehaan howsimianvirus40hijackstheintracellularproteintraffickingpathwaytoitsownbenefitandours |