Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here
Oxidative stress (OxS) is one of the main processes related to aging and a common denominator of many different chronic/degenerative diseases (e.g., cardiovascular and neurodegenerative conditions and cancer). Thus, its potential modulation by supplementation/pharmacological therapy caused a lot of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/11/2653 |
| _version_ | 1797565889259765760 |
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| author | Cristina Vassalle Maristella Maltinti Laura Sabatino |
| author_facet | Cristina Vassalle Maristella Maltinti Laura Sabatino |
| author_sort | Cristina Vassalle |
| collection | DOAJ |
| description | Oxidative stress (OxS) is one of the main processes related to aging and a common denominator of many different chronic/degenerative diseases (e.g., cardiovascular and neurodegenerative conditions and cancer). Thus, its potential modulation by supplementation/pharmacological therapy caused a lot of interest. However, these expectations have been mitigated by the obtainment of controversial results (beneficial, null, or adverse effects) following antioxidant interventions. Here, we discuss the current understanding of OxS assessment in health and disease, challenges and the potential of its evaluation in clinical practice, and available and future development for supplementation and pharmacologic strategies targeting OxS. |
| first_indexed | 2024-03-10T19:19:19Z |
| format | Article |
| id | doaj.art-d1604658970b4e0aa65bf8320ac41863 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:19:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d1604658970b4e0aa65bf8320ac418632023-11-20T03:07:55ZengMDPI AGMolecules1420-30492020-06-012511265310.3390/molecules25112653Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from HereCristina Vassalle0Maristella Maltinti1Laura Sabatino2Fondazione CNR-Regione Toscana G Monasterio, 56124 Pisa, ItalyFondazione CNR-Regione Toscana G Monasterio, 56124 Pisa, ItalyInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyOxidative stress (OxS) is one of the main processes related to aging and a common denominator of many different chronic/degenerative diseases (e.g., cardiovascular and neurodegenerative conditions and cancer). Thus, its potential modulation by supplementation/pharmacological therapy caused a lot of interest. However, these expectations have been mitigated by the obtainment of controversial results (beneficial, null, or adverse effects) following antioxidant interventions. Here, we discuss the current understanding of OxS assessment in health and disease, challenges and the potential of its evaluation in clinical practice, and available and future development for supplementation and pharmacologic strategies targeting OxS.https://www.mdpi.com/1420-3049/25/11/2653oxidative stressbloodpharmacological targetantioxidant supplementationdisease preventiondisease therapy |
| spellingShingle | Cristina Vassalle Maristella Maltinti Laura Sabatino Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here Molecules oxidative stress blood pharmacological target antioxidant supplementation disease prevention disease therapy |
| title | Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here |
| title_full | Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here |
| title_fullStr | Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here |
| title_full_unstemmed | Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here |
| title_short | Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here |
| title_sort | targeting oxidative stress for disease prevention and therapy where do we stand and where do we go from here |
| topic | oxidative stress blood pharmacological target antioxidant supplementation disease prevention disease therapy |
| url | https://www.mdpi.com/1420-3049/25/11/2653 |
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