Osteopontin – A potential biomarker of advanced liver disease
Cirrhosis is a primary cause of liver-related mortality and morbidity. The basic process driving chronic liver disease to cirrhosis is accelerated fibrogenesis. Although the pathogenesis of liver cirrhosis is a multifactorial process, the essential step in the evolution of liver fibrosis is the acti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268120300016 |
| _version_ | 1818608240891527168 |
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| author | Radan Bruha Libor Vitek Vaclav Smid |
| author_facet | Radan Bruha Libor Vitek Vaclav Smid |
| author_sort | Radan Bruha |
| collection | DOAJ |
| description | Cirrhosis is a primary cause of liver-related mortality and morbidity. The basic process driving chronic liver disease to cirrhosis is accelerated fibrogenesis. Although the pathogenesis of liver cirrhosis is a multifactorial process, the essential step in the evolution of liver fibrosis is the activation of hepatic stellate cells, which are the main source of collagen produced in the extracellular matrix. This activation process is mediated by multiple growth factors, cytokines, and chemokines. One of the hepatic stellate cell-activating signaling molecules (and also one associated with cell injury and fibrosis) is osteopontin (OPN). OPN concentration in the plasma has been found to be predictive of liver fibrosis in various liver diseases. OPN concentrations correlate significantly with the stage of fibrosis, liver insufficiency, portal hypertension, and the presence of hepatocellular cancer. However, due to its versatile signaling functions, OPN not only contributes to the development of liver cirrhosis, but is also implicated in the pathogenesis of other chronic hepatic diseases such as viral hepatitis, both alcoholic and non-alcoholic steatohepatitis, drug-induced liver injury, and hepatocellular cancer. Thus, the targeting of OPN pathways seems to be a promising approach in the treatment of chronic liver diseases. |
| first_indexed | 2024-12-16T14:39:30Z |
| format | Article |
| id | doaj.art-d1605cba297b463d9912bb76335e1864 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T14:39:30Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-d1605cba297b463d9912bb76335e18642022-12-21T22:28:00ZengElsevierAnnals of Hepatology1665-26812020-07-01194344352Osteopontin – A potential biomarker of advanced liver diseaseRadan Bruha0Libor Vitek1Vaclav Smid2Charles University in Prague, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, U Nemocnice 2, Prague, Czech Republic; Corresponding author.Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Institute of Medical Biochemistry and Laboratory Diagnostics, U Nemocnice 2, Prague, Czech RepublicCharles University in Prague, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, U Nemocnice 2, Prague, Czech RepublicCirrhosis is a primary cause of liver-related mortality and morbidity. The basic process driving chronic liver disease to cirrhosis is accelerated fibrogenesis. Although the pathogenesis of liver cirrhosis is a multifactorial process, the essential step in the evolution of liver fibrosis is the activation of hepatic stellate cells, which are the main source of collagen produced in the extracellular matrix. This activation process is mediated by multiple growth factors, cytokines, and chemokines. One of the hepatic stellate cell-activating signaling molecules (and also one associated with cell injury and fibrosis) is osteopontin (OPN). OPN concentration in the plasma has been found to be predictive of liver fibrosis in various liver diseases. OPN concentrations correlate significantly with the stage of fibrosis, liver insufficiency, portal hypertension, and the presence of hepatocellular cancer. However, due to its versatile signaling functions, OPN not only contributes to the development of liver cirrhosis, but is also implicated in the pathogenesis of other chronic hepatic diseases such as viral hepatitis, both alcoholic and non-alcoholic steatohepatitis, drug-induced liver injury, and hepatocellular cancer. Thus, the targeting of OPN pathways seems to be a promising approach in the treatment of chronic liver diseases.http://www.sciencedirect.com/science/article/pii/S1665268120300016CirrhosisHepatocellular cancerLiver fibrosisNon-alcoholic fatty liver diseaseOsteopontinPortal hypertension |
| spellingShingle | Radan Bruha Libor Vitek Vaclav Smid Osteopontin – A potential biomarker of advanced liver disease Annals of Hepatology Cirrhosis Hepatocellular cancer Liver fibrosis Non-alcoholic fatty liver disease Osteopontin Portal hypertension |
| title | Osteopontin – A potential biomarker of advanced liver disease |
| title_full | Osteopontin – A potential biomarker of advanced liver disease |
| title_fullStr | Osteopontin – A potential biomarker of advanced liver disease |
| title_full_unstemmed | Osteopontin – A potential biomarker of advanced liver disease |
| title_short | Osteopontin – A potential biomarker of advanced liver disease |
| title_sort | osteopontin a potential biomarker of advanced liver disease |
| topic | Cirrhosis Hepatocellular cancer Liver fibrosis Non-alcoholic fatty liver disease Osteopontin Portal hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S1665268120300016 |
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