Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke
Background: The literature on upper limb robot-assisted therapy showed that robot-measured metrics can simultaneously predict registered clinical outcomes. However, only a limited number of studies correlated pre-treatment kinematics with discharge motor recovery. Given the importance of predicting...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1012544/full |
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| author | Michela Goffredo Stefania Proietti Stefania Proietti Sanaz Pournajaf Daniele Galafate Matteo Cioeta Domenica Le Pera Federico Posteraro Marco Franceschini Marco Franceschini |
| author_facet | Michela Goffredo Stefania Proietti Stefania Proietti Sanaz Pournajaf Daniele Galafate Matteo Cioeta Domenica Le Pera Federico Posteraro Marco Franceschini Marco Franceschini |
| author_sort | Michela Goffredo |
| collection | DOAJ |
| description | Background: The literature on upper limb robot-assisted therapy showed that robot-measured metrics can simultaneously predict registered clinical outcomes. However, only a limited number of studies correlated pre-treatment kinematics with discharge motor recovery. Given the importance of predicting rehabilitation outcomes for optimizing physical therapy, a predictive model for motor recovery that incorporates multidirectional indicators of a patient’s upper limb abilities is needed.Objective: The aim of this study was to develop a predictive model for rehabilitation outcome at discharge (i.e., muscle strength assessed by the Motricity Index of the affected upper limb) based on multidirectional 2D robot-measured kinematics.Methods: Re-analysis of data from 66 subjects with subacute stroke who underwent upper limb robot-assisted therapy with an end-effector robot was performed. Two least squares error multiple linear regression models for outcome prediction were developed and differ in terms of validation procedure: the Split Sample Validation (SSV) model and the Leave-One-Out Cross-Validation (LOOCV) model. In both models, the outputs were the discharge Motricity Index of the affected upper limb and its sub-items assessing elbow flexion and shoulder abduction, while the inputs were the admission robot-measured metrics.Results: The extracted robot-measured features explained the 54% and 71% of the variance in clinical scores at discharge in the SSV and LOOCV validation procedures respectively. Normalized errors ranged from 22% to 35% in the SSV models and from 20% to 24% in the LOOCV models. In all models, the movement path error of the trajectories characterized by elbow flexion and shoulder extension was the significant predictor, and all correlations were significant.Conclusion: This study highlights that motor patterns assessed with multidirectional 2D robot-measured metrics are able to predict clinical evalutation of upper limb muscle strength and may be useful for clinicians to assess, manage, and program a more specific and appropriate rehabilitation in subacute stroke patients. |
| first_indexed | 2024-04-11T13:35:54Z |
| format | Article |
| id | doaj.art-d163fcf34f6842fab58d26350fa9f4d3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T13:35:54Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d163fcf34f6842fab58d26350fa9f4d32022-12-22T04:21:29ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-12-011010.3389/fbioe.2022.10125441012544Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute strokeMichela Goffredo0Stefania Proietti1Stefania Proietti2Sanaz Pournajaf3Daniele Galafate4Matteo Cioeta5Domenica Le Pera6Federico Posteraro7Marco Franceschini8Marco Franceschini9Department of Neurological and Rehabilitation Sciences, IRCCS San Raffaele Roma, Rome, ItalyUnit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Rome, ItalyDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Rome, ItalyDepartment of Neurological and Rehabilitation Sciences, IRCCS San Raffaele Roma, Rome, ItalyDepartment of Neurological and Rehabilitation Sciences, IRCCS San Raffaele Roma, Rome, ItalyDepartment of Neurological and Rehabilitation Sciences, IRCCS San Raffaele Roma, Rome, ItalyDepartment of Neurological and Rehabilitation Sciences, IRCCS San Raffaele Roma, Rome, ItalyRehabilitation Department, Versilia Hospital, Camaiore, ItalyDepartment of Neurological and Rehabilitation Sciences, IRCCS San Raffaele Roma, Rome, ItalyDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Rome, ItalyBackground: The literature on upper limb robot-assisted therapy showed that robot-measured metrics can simultaneously predict registered clinical outcomes. However, only a limited number of studies correlated pre-treatment kinematics with discharge motor recovery. Given the importance of predicting rehabilitation outcomes for optimizing physical therapy, a predictive model for motor recovery that incorporates multidirectional indicators of a patient’s upper limb abilities is needed.Objective: The aim of this study was to develop a predictive model for rehabilitation outcome at discharge (i.e., muscle strength assessed by the Motricity Index of the affected upper limb) based on multidirectional 2D robot-measured kinematics.Methods: Re-analysis of data from 66 subjects with subacute stroke who underwent upper limb robot-assisted therapy with an end-effector robot was performed. Two least squares error multiple linear regression models for outcome prediction were developed and differ in terms of validation procedure: the Split Sample Validation (SSV) model and the Leave-One-Out Cross-Validation (LOOCV) model. In both models, the outputs were the discharge Motricity Index of the affected upper limb and its sub-items assessing elbow flexion and shoulder abduction, while the inputs were the admission robot-measured metrics.Results: The extracted robot-measured features explained the 54% and 71% of the variance in clinical scores at discharge in the SSV and LOOCV validation procedures respectively. Normalized errors ranged from 22% to 35% in the SSV models and from 20% to 24% in the LOOCV models. In all models, the movement path error of the trajectories characterized by elbow flexion and shoulder extension was the significant predictor, and all correlations were significant.Conclusion: This study highlights that motor patterns assessed with multidirectional 2D robot-measured metrics are able to predict clinical evalutation of upper limb muscle strength and may be useful for clinicians to assess, manage, and program a more specific and appropriate rehabilitation in subacute stroke patients.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1012544/fullrobot-assisted therapystrokemotor recoveryupper extremitykinematicsbiomarkers |
| spellingShingle | Michela Goffredo Stefania Proietti Stefania Proietti Sanaz Pournajaf Daniele Galafate Matteo Cioeta Domenica Le Pera Federico Posteraro Marco Franceschini Marco Franceschini Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke Frontiers in Bioengineering and Biotechnology robot-assisted therapy stroke motor recovery upper extremity kinematics biomarkers |
| title | Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke |
| title_full | Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke |
| title_fullStr | Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke |
| title_full_unstemmed | Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke |
| title_short | Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke |
| title_sort | baseline robot measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke |
| topic | robot-assisted therapy stroke motor recovery upper extremity kinematics biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1012544/full |
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