LRP1B: A Giant Lost in Cancer Translation
Low-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell signaling. LRP1B is among the most altered genes in h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/9/836 |
| _version_ | 1797517687595728896 |
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| author | Catarina Príncipe Isabel J. Dionísio de Sousa Hugo Prazeres Paula Soares Raquel T. Lima |
| author_facet | Catarina Príncipe Isabel J. Dionísio de Sousa Hugo Prazeres Paula Soares Raquel T. Lima |
| author_sort | Catarina Príncipe |
| collection | DOAJ |
| description | Low-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell signaling. LRP1B is among the most altered genes in human cancer overall. Found frequently inactivated by several genetic and epigenetic mechanisms, it has mostly been regarded as a putative tumor suppressor. Still, limitations in LRP1B studies exist, in particular associated with its huge size. Therefore, LRP1B expression and function in cancer remains to be fully unveiled. This review addresses the current understanding of LRP1B and the studies that shed a light on the LRP1B structure and ligands. It goes further in presenting increasing knowledge brought by technical and methodological advances that allow to better manipulate LRP1B expression in cells and to more thoroughly explore its expression and mutation status. New evidence is pushing towards the increased relevance of LRP1B in cancer as a potential target or translational prognosis and response to therapy biomarker. |
| first_indexed | 2024-03-10T07:19:40Z |
| format | Article |
| id | doaj.art-d164f4383b0d4e08b3ebf8a9e0d3be80 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T07:19:40Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d164f4383b0d4e08b3ebf8a9e0d3be802023-11-22T14:44:06ZengMDPI AGPharmaceuticals1424-82472021-08-0114983610.3390/ph14090836LRP1B: A Giant Lost in Cancer TranslationCatarina Príncipe0Isabel J. Dionísio de Sousa1Hugo Prazeres2Paula Soares3Raquel T. Lima4i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalDepartment of Oncology, Centro Hospitalar Universitário de São João, 4200-450 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalLow-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell signaling. LRP1B is among the most altered genes in human cancer overall. Found frequently inactivated by several genetic and epigenetic mechanisms, it has mostly been regarded as a putative tumor suppressor. Still, limitations in LRP1B studies exist, in particular associated with its huge size. Therefore, LRP1B expression and function in cancer remains to be fully unveiled. This review addresses the current understanding of LRP1B and the studies that shed a light on the LRP1B structure and ligands. It goes further in presenting increasing knowledge brought by technical and methodological advances that allow to better manipulate LRP1B expression in cells and to more thoroughly explore its expression and mutation status. New evidence is pushing towards the increased relevance of LRP1B in cancer as a potential target or translational prognosis and response to therapy biomarker.https://www.mdpi.com/1424-8247/14/9/836LRP1Bendocytic receptorcancertumor suppressorbiomarkerprognosis |
| spellingShingle | Catarina Príncipe Isabel J. Dionísio de Sousa Hugo Prazeres Paula Soares Raquel T. Lima LRP1B: A Giant Lost in Cancer Translation Pharmaceuticals LRP1B endocytic receptor cancer tumor suppressor biomarker prognosis |
| title | LRP1B: A Giant Lost in Cancer Translation |
| title_full | LRP1B: A Giant Lost in Cancer Translation |
| title_fullStr | LRP1B: A Giant Lost in Cancer Translation |
| title_full_unstemmed | LRP1B: A Giant Lost in Cancer Translation |
| title_short | LRP1B: A Giant Lost in Cancer Translation |
| title_sort | lrp1b a giant lost in cancer translation |
| topic | LRP1B endocytic receptor cancer tumor suppressor biomarker prognosis |
| url | https://www.mdpi.com/1424-8247/14/9/836 |
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