Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model
Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) is an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water and ethanol-water extracts administrations on oxidative stres...
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| Format: | Article |
| Language: | English |
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Hitit University
2022-12-01
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| Series: | Hittite Journal of Science and Engineering |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2593327 |
| _version_ | 1797662755222716416 |
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| author | Kaan Kaltalıoğlu |
| author_facet | Kaan Kaltalıoğlu |
| author_sort | Kaan Kaltalıoğlu |
| collection | DOAJ |
| description | Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) is an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water and ethanol-water extracts administrations on oxidative stress in paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, negative control (2 g/kg paracetamol), PL fruit water extract (400 mg/kg PLW+ 2 g/kg paracetamol), PL fruit ethanol-water extract (400 mg/kg PLEW+ 2 g/kg paracetamol) and positive control (150 mg/kg NAC+ 2 g/kg paracetamol). 24 hours after the paracetamol induction, animals were sacrificed and oxidative parameters were analyzed spectrophotometrically in kidney tissue. PLW and PLEW extracts decreased MDA and NOx levels and increased SOD and CAT activities in paracetamol-induced nephrotoxicity. PL fruit extracts can restore the oxidative changes caused by paracetamol. |
| first_indexed | 2024-03-11T19:03:44Z |
| format | Article |
| id | doaj.art-d165371944a346e29502dcac50ce8079 |
| institution | Directory Open Access Journal |
| issn | 2148-4171 |
| language | English |
| last_indexed | 2024-03-11T19:03:44Z |
| publishDate | 2022-12-01 |
| publisher | Hitit University |
| record_format | Article |
| series | Hittite Journal of Science and Engineering |
| spelling | doaj.art-d165371944a346e29502dcac50ce80792023-10-10T11:17:26ZengHitit UniversityHittite Journal of Science and Engineering2148-41712022-12-019427528010.17350/HJSE19030000280150Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal ModelKaan Kaltalıoğlu0GİRESUN ÜNİVERSİTESİParacetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) is an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water and ethanol-water extracts administrations on oxidative stress in paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, negative control (2 g/kg paracetamol), PL fruit water extract (400 mg/kg PLW+ 2 g/kg paracetamol), PL fruit ethanol-water extract (400 mg/kg PLEW+ 2 g/kg paracetamol) and positive control (150 mg/kg NAC+ 2 g/kg paracetamol). 24 hours after the paracetamol induction, animals were sacrificed and oxidative parameters were analyzed spectrophotometrically in kidney tissue. PLW and PLEW extracts decreased MDA and NOx levels and increased SOD and CAT activities in paracetamol-induced nephrotoxicity. PL fruit extracts can restore the oxidative changes caused by paracetamol.https://dergipark.org.tr/tr/download/article-file/2593327antioxidantsnephrotoxicityoxidative stressparacetamolprunus laurocerasus |
| spellingShingle | Kaan Kaltalıoğlu Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model Hittite Journal of Science and Engineering antioxidants nephrotoxicity oxidative stress paracetamol prunus laurocerasus |
| title | Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model |
| title_full | Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model |
| title_fullStr | Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model |
| title_full_unstemmed | Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model |
| title_short | Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model |
| title_sort | prunus laurocerasus l extracts prevent paracetamolinduced nephrotoxicity by regulating antioxidant status an experimental animal model |
| topic | antioxidants nephrotoxicity oxidative stress paracetamol prunus laurocerasus |
| url | https://dergipark.org.tr/tr/download/article-file/2593327 |
| work_keys_str_mv | AT kaankaltalıoglu prunuslaurocerasuslextractspreventparacetamolinducednephrotoxicitybyregulatingantioxidantstatusanexperimentalanimalmodel |