Explicit B-spline regularization in diffeomorphic image registration

Diffeomorphic mappings are central to image registration due largely to their topological properties and success in providing biologically plausible solutions to deformation and morphological estimation problems. Popular diffeomorphic image registration algorithms include those characterized by time...

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Main Authors: Nicholas James Tustison, Brian eAvants
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Neuroinformatics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fninf.2013.00039/full
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author Nicholas James Tustison
Brian eAvants
author_facet Nicholas James Tustison
Brian eAvants
author_sort Nicholas James Tustison
collection DOAJ
description Diffeomorphic mappings are central to image registration due largely to their topological properties and success in providing biologically plausible solutions to deformation and morphological estimation problems. Popular diffeomorphic image registration algorithms include those characterized by time-varying and constant velocity fields, and symmetrical considerations. Prior information in the form of regularization is used to enforce transform plausibility taking the form of physics-based constraints or through some approximation thereof, e.g. Gaussian smoothing of the vector fields (a la Thirion's Demons citep{thirion1998}). In the context of the original Demons' framework, the so-called {it directly manipulated free-form deformation} citep{tustison2009} can be viewed as a smoothing alternative in which explicit regularization is achieved through fast B-spline approximation. This characterization can be used to provide B-spline ``flavored'' diffeomorphic image registration solutions with several advantages. Implementation is open source and available through the Insight Toolkit and our Advanced Normalization Tools (ANTs) repository. A thorough comparative evaluation with the well-known SyN algorithm citep{avants2008}, implemented within the same framework, and its B-spline analog is performed using open labeled brain data and open source evaluation tools.
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spelling doaj.art-d1658561f2514ed6a3032a20fd0ff6492022-12-22T02:33:50ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962013-12-01710.3389/fninf.2013.0003973124Explicit B-spline regularization in diffeomorphic image registrationNicholas James Tustison0Brian eAvants1University of VirginiaUniversity of PennsylvaniaDiffeomorphic mappings are central to image registration due largely to their topological properties and success in providing biologically plausible solutions to deformation and morphological estimation problems. Popular diffeomorphic image registration algorithms include those characterized by time-varying and constant velocity fields, and symmetrical considerations. Prior information in the form of regularization is used to enforce transform plausibility taking the form of physics-based constraints or through some approximation thereof, e.g. Gaussian smoothing of the vector fields (a la Thirion's Demons citep{thirion1998}). In the context of the original Demons' framework, the so-called {it directly manipulated free-form deformation} citep{tustison2009} can be viewed as a smoothing alternative in which explicit regularization is achieved through fast B-spline approximation. This characterization can be used to provide B-spline ``flavored'' diffeomorphic image registration solutions with several advantages. Implementation is open source and available through the Insight Toolkit and our Advanced Normalization Tools (ANTs) repository. A thorough comparative evaluation with the well-known SyN algorithm citep{avants2008}, implemented within the same framework, and its B-spline analog is performed using open labeled brain data and open source evaluation tools.http://journal.frontiersin.org/Journal/10.3389/fninf.2013.00039/fullspatial normalizationDiffeomorphismsInsight ToolkitAdvanced Normalization Toolsdirectly manipulated free-form deformation
spellingShingle Nicholas James Tustison
Brian eAvants
Explicit B-spline regularization in diffeomorphic image registration
Frontiers in Neuroinformatics
spatial normalization
Diffeomorphisms
Insight Toolkit
Advanced Normalization Tools
directly manipulated free-form deformation
title Explicit B-spline regularization in diffeomorphic image registration
title_full Explicit B-spline regularization in diffeomorphic image registration
title_fullStr Explicit B-spline regularization in diffeomorphic image registration
title_full_unstemmed Explicit B-spline regularization in diffeomorphic image registration
title_short Explicit B-spline regularization in diffeomorphic image registration
title_sort explicit b spline regularization in diffeomorphic image registration
topic spatial normalization
Diffeomorphisms
Insight Toolkit
Advanced Normalization Tools
directly manipulated free-form deformation
url http://journal.frontiersin.org/Journal/10.3389/fninf.2013.00039/full
work_keys_str_mv AT nicholasjamestustison explicitbsplineregularizationindiffeomorphicimageregistration
AT brianeavants explicitbsplineregularizationindiffeomorphicimageregistration