Current treatment options for acanthosis nigricans
Nupur U Patel,1 Catherine Roach,1 Hossein Alinia,1 William W Huang,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, 2Department of Pathology, Wake Forest University School of Medicine, Winston-S...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-08-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/current-treatment-options-for-acanthosis-nigricans-peer-reviewed-article-CCID |
| _version_ | 1818239891947913216 |
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| author | Patel NU Roach C Alinia H Huang WW Feldman SR |
| author_facet | Patel NU Roach C Alinia H Huang WW Feldman SR |
| author_sort | Patel NU |
| collection | DOAJ |
| description | Nupur U Patel,1 Catherine Roach,1 Hossein Alinia,1 William W Huang,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, 2Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, 3Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. While the goal of therapy is to treat the primary cause, cosmetic resolution of AN lesions can be important for patients and their quality of life. Treatment options for AN have not been extensively studied; however, smaller powered clinical trials and case reports exist in the literature. Our review aims to explore and evaluate the current treatment options that exist for AN. Keywords: acanthosis nigricans, diabetes, obesity, hyperinsulinemia, dermatologic condition, dermatology, malignant acanthosis, pseudoacanthosis, metformin, isotretinoin, tretinoin, topical therapy |
| first_indexed | 2024-12-12T13:04:45Z |
| format | Article |
| id | doaj.art-d1675d0eaae24d01bf046f4b31538788 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-12T13:04:45Z |
| publishDate | 2018-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-d1675d0eaae24d01bf046f4b315387882022-12-22T00:23:42ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152018-08-01Volume 1140741339722Current treatment options for acanthosis nigricansPatel NURoach CAlinia HHuang WWFeldman SRNupur U Patel,1 Catherine Roach,1 Hossein Alinia,1 William W Huang,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, 2Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, 3Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. While the goal of therapy is to treat the primary cause, cosmetic resolution of AN lesions can be important for patients and their quality of life. Treatment options for AN have not been extensively studied; however, smaller powered clinical trials and case reports exist in the literature. Our review aims to explore and evaluate the current treatment options that exist for AN. Keywords: acanthosis nigricans, diabetes, obesity, hyperinsulinemia, dermatologic condition, dermatology, malignant acanthosis, pseudoacanthosis, metformin, isotretinoin, tretinoin, topical therapyhttps://www.dovepress.com/current-treatment-options-for-acanthosis-nigricans-peer-reviewed-article-CCIDacanthosis nigricansdiabetesobesityhyperinsulinemiadermatologic conditiondermatologymalignant acanthosispseudoacanthosismetforminisotretinointretinointopical therapy |
| spellingShingle | Patel NU Roach C Alinia H Huang WW Feldman SR Current treatment options for acanthosis nigricans Clinical, Cosmetic and Investigational Dermatology acanthosis nigricans diabetes obesity hyperinsulinemia dermatologic condition dermatology malignant acanthosis pseudoacanthosis metformin isotretinoin tretinoin topical therapy |
| title | Current treatment options for acanthosis nigricans |
| title_full | Current treatment options for acanthosis nigricans |
| title_fullStr | Current treatment options for acanthosis nigricans |
| title_full_unstemmed | Current treatment options for acanthosis nigricans |
| title_short | Current treatment options for acanthosis nigricans |
| title_sort | current treatment options for acanthosis nigricans |
| topic | acanthosis nigricans diabetes obesity hyperinsulinemia dermatologic condition dermatology malignant acanthosis pseudoacanthosis metformin isotretinoin tretinoin topical therapy |
| url | https://www.dovepress.com/current-treatment-options-for-acanthosis-nigricans-peer-reviewed-article-CCID |
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