The Application of Inosine 5′-Monophosphate Dehydrogenase Activity Determination in Peripheral Blood Mononuclear Cells for Monitoring Mycophenolate Mofetil Therapy in Children with Nephrotic Syndrome

The Application of Inosine 5′-Monophosphate Dehydrogenase Activity Determination in Peripheral Blood Mononuclear Cells for Monitoring Mycophenolate Mofetil Therapy in Children with Nephrotic Syndrome

In pediatric nephrotic syndrome, recommended mycophenolic acid (MPA) pharmacokinetics are higher than those for transplant recipients. In MPA therapeutic monitoring, inosine-5′-monophosphate dehydrogenase (IMPDH) activity may be useful. We modified the method established for renal transplant recipie...

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Bibliographic Details
Main Authors: Joanna Sobiak, Alicja Jóźwiak, Honorata Wziętek, Jacek Zachwieja, Danuta Ostalska-Nowicka
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceuticals
Subjects:
mycophenolic acid
inosine-5′-monophosphate dehydrogenase activity
pediatric patients
HPLC method
therapeutic drug monitoring
nephrotic syndrome
Online Access:https://www.mdpi.com/1424-8247/13/8/200

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