Melatonin Target Proteins: Too Many or Not Enough?
The neurohormone N-acetyl-5-methoxytryptamine, better known as melatonin, is a tryptophan derivative with a wide range of biological effects that is present in many organisms. These effects are believed to rely either on the chemical properties of melatonin itself as scavenger of free radicals or on...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00791/full |
| _version_ | 1818039970491793408 |
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| author | Lei Liu Lei Liu Nedjma Labani Nedjma Labani Erika Cecon Ralf Jockers |
| author_facet | Lei Liu Lei Liu Nedjma Labani Nedjma Labani Erika Cecon Ralf Jockers |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | The neurohormone N-acetyl-5-methoxytryptamine, better known as melatonin, is a tryptophan derivative with a wide range of biological effects that is present in many organisms. These effects are believed to rely either on the chemical properties of melatonin itself as scavenger of free radicals or on the binding of melatonin to protein targets. More than 15 proteins, including receptors (MT1, MT2, Mel1c, CAND2, ROR, VDR), enzymes (QR2, MMP-9, pepsin, PP2A, PR-10 proteins), pores (mtPTP), transporters (PEPT1/2, Glut1), and other proteins (HBS, CaM, tubulin, calreticuline), have been suggested to interact with melatonin at sub-nanomolar to millimolar melatonin concentrations. In this review we assemble for the first time the available information on proposed melatonin targets and discuss them in a comprehensive manner to evaluate the robustness of these findings in terms of methodology, physiological relevance, and independent replication. |
| first_indexed | 2024-12-10T08:07:06Z |
| format | Article |
| id | doaj.art-d168b5ecb59e4d4982b3279bc1a4871b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T08:07:06Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d168b5ecb59e4d4982b3279bc1a4871b2022-12-22T01:56:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-11-011010.3389/fendo.2019.00791492611Melatonin Target Proteins: Too Many or Not Enough?Lei Liu0Lei Liu1Nedjma Labani2Nedjma Labani3Erika Cecon4Ralf Jockers5Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, FranceCellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, FranceUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, FranceUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, FranceThe neurohormone N-acetyl-5-methoxytryptamine, better known as melatonin, is a tryptophan derivative with a wide range of biological effects that is present in many organisms. These effects are believed to rely either on the chemical properties of melatonin itself as scavenger of free radicals or on the binding of melatonin to protein targets. More than 15 proteins, including receptors (MT1, MT2, Mel1c, CAND2, ROR, VDR), enzymes (QR2, MMP-9, pepsin, PP2A, PR-10 proteins), pores (mtPTP), transporters (PEPT1/2, Glut1), and other proteins (HBS, CaM, tubulin, calreticuline), have been suggested to interact with melatonin at sub-nanomolar to millimolar melatonin concentrations. In this review we assemble for the first time the available information on proposed melatonin targets and discuss them in a comprehensive manner to evaluate the robustness of these findings in terms of methodology, physiological relevance, and independent replication.https://www.frontiersin.org/article/10.3389/fendo.2019.00791/fullmelatoninGPCRQR2RORPR-10MMP-9 |
| spellingShingle | Lei Liu Lei Liu Nedjma Labani Nedjma Labani Erika Cecon Ralf Jockers Melatonin Target Proteins: Too Many or Not Enough? Frontiers in Endocrinology melatonin GPCR QR2 ROR PR-10 MMP-9 |
| title | Melatonin Target Proteins: Too Many or Not Enough? |
| title_full | Melatonin Target Proteins: Too Many or Not Enough? |
| title_fullStr | Melatonin Target Proteins: Too Many or Not Enough? |
| title_full_unstemmed | Melatonin Target Proteins: Too Many or Not Enough? |
| title_short | Melatonin Target Proteins: Too Many or Not Enough? |
| title_sort | melatonin target proteins too many or not enough |
| topic | melatonin GPCR QR2 ROR PR-10 MMP-9 |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00791/full |
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