Melatonin for the Management of Preeclampsia: A Review
Preeclampsia is a disease specific to pregnancy characterised by new-onset hypertension with maternal organ dysfunction and/or fetal growth restriction. It remains a major cause of maternal and perinatal morbidity and mortality. For sixty years, antihypertensives have been the mainstay of treating p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/3/376 |
| _version_ | 1797415211694555136 |
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| author | Annie Langston-Cox Sarah A. Marshall Daisy Lu Kirsten R. Palmer Euan M. Wallace |
| author_facet | Annie Langston-Cox Sarah A. Marshall Daisy Lu Kirsten R. Palmer Euan M. Wallace |
| author_sort | Annie Langston-Cox |
| collection | DOAJ |
| description | Preeclampsia is a disease specific to pregnancy characterised by new-onset hypertension with maternal organ dysfunction and/or fetal growth restriction. It remains a major cause of maternal and perinatal morbidity and mortality. For sixty years, antihypertensives have been the mainstay of treating preeclampsia and only recently have insights into the pathogenesis of the disease opened new avenues for novel therapies. Melatonin is one such option, an endogenous and safe antioxidant, that may improve the maternal condition in preeclampsia while protecting the fetus from a hostile intrauterine environment. Here we review the evidence for melatonin as a possible adjuvant therapy for preeclampsia, including in vitro evidence supporting a role for melatonin in protecting the human placenta, preclinical models, vascular studies, and clinical studies in hypertension and pregnancy. |
| first_indexed | 2024-03-09T05:44:35Z |
| format | Article |
| id | doaj.art-d1693b21e08a4ddd974c05d4ff677d61 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T05:44:35Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-d1693b21e08a4ddd974c05d4ff677d612023-12-03T12:22:39ZengMDPI AGAntioxidants2076-39212021-03-0110337610.3390/antiox10030376Melatonin for the Management of Preeclampsia: A ReviewAnnie Langston-Cox0Sarah A. Marshall1Daisy Lu2Kirsten R. Palmer3Euan M. Wallace4The Ritchie Centre, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaPreeclampsia is a disease specific to pregnancy characterised by new-onset hypertension with maternal organ dysfunction and/or fetal growth restriction. It remains a major cause of maternal and perinatal morbidity and mortality. For sixty years, antihypertensives have been the mainstay of treating preeclampsia and only recently have insights into the pathogenesis of the disease opened new avenues for novel therapies. Melatonin is one such option, an endogenous and safe antioxidant, that may improve the maternal condition in preeclampsia while protecting the fetus from a hostile intrauterine environment. Here we review the evidence for melatonin as a possible adjuvant therapy for preeclampsia, including in vitro evidence supporting a role for melatonin in protecting the human placenta, preclinical models, vascular studies, and clinical studies in hypertension and pregnancy.https://www.mdpi.com/2076-3921/10/3/376preeclampsiamelatoninantioxidantplacental biologymitochondrial function |
| spellingShingle | Annie Langston-Cox Sarah A. Marshall Daisy Lu Kirsten R. Palmer Euan M. Wallace Melatonin for the Management of Preeclampsia: A Review Antioxidants preeclampsia melatonin antioxidant placental biology mitochondrial function |
| title | Melatonin for the Management of Preeclampsia: A Review |
| title_full | Melatonin for the Management of Preeclampsia: A Review |
| title_fullStr | Melatonin for the Management of Preeclampsia: A Review |
| title_full_unstemmed | Melatonin for the Management of Preeclampsia: A Review |
| title_short | Melatonin for the Management of Preeclampsia: A Review |
| title_sort | melatonin for the management of preeclampsia a review |
| topic | preeclampsia melatonin antioxidant placental biology mitochondrial function |
| url | https://www.mdpi.com/2076-3921/10/3/376 |
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