NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells
(1) Background: Upconversion nanoparticles (UCNPs) are a promising tool for biological tissue structure visualization and photodynamic therapy (PDT). The luminescence of such NPs is excited in the spectrum’s near-infrared (NIR) region, while the NPs luminesce in the visible region. Conjugating such...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/10/12/1386 |
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| author | Anna A. Doronkina Vyacheslav I. Kochubey Anastasia V. Maksutova Alexander B. Pravdin Artem M. Mylnikov Nikita A. Navolokin Irina Yu. Yanina |
| author_facet | Anna A. Doronkina Vyacheslav I. Kochubey Anastasia V. Maksutova Alexander B. Pravdin Artem M. Mylnikov Nikita A. Navolokin Irina Yu. Yanina |
| author_sort | Anna A. Doronkina |
| collection | DOAJ |
| description | (1) Background: Upconversion nanoparticles (UCNPs) are a promising tool for biological tissue structure visualization and photodynamic therapy (PDT). The luminescence of such NPs is excited in the spectrum’s near-infrared (NIR) region, while the NPs luminesce in the visible region. Conjugating such NPs with photodynamic dyes that absorb their luminescence makes it possible to increase the depth at which PDT is performed. (2) Methods: We conducted a comprehensive study on the possibility of using NaYF<sub>4</sub>:Er:Yb UCNPs in vivo for imaging and PDT. The NPs were synthesized by a hydrothermal method. The synthesis of NPs with a size of 80 nm and hexagonal structure was demonstrated. (3) Results: The accumulation of NPs in organs after their intravenous injection into rats was studied. The effect of NPs on the shape, size, and degree of aggregation of red blood cells (RBC) was also investigated. (4) Conclusions: The possibility of luminescent visualization of NPs in histological sections and their subcutaneous distribution is demonstrated. All investigated particles showed moderate toxicity, causing mostly reversible changes. |
| first_indexed | 2024-03-08T20:26:25Z |
| format | Article |
| id | doaj.art-d16964af60414182b87d8c291f7088b3 |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-08T20:26:25Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-d16964af60414182b87d8c291f7088b32023-12-22T14:33:02ZengMDPI AGPhotonics2304-67322023-12-011012138610.3390/photonics10121386NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood CellsAnna A. Doronkina0Vyacheslav I. Kochubey1Anastasia V. Maksutova2Alexander B. Pravdin3Artem M. Mylnikov4Nikita A. Navolokin5Irina Yu. Yanina6Institution of Physics, Saratov State University, 410012 Saratov, RussiaInstitution of Physics, Saratov State University, 410012 Saratov, RussiaInstitution of Physics, Saratov State University, 410012 Saratov, RussiaInstitution of Physics, Saratov State University, 410012 Saratov, RussiaDepartment of Pathological Anatomy, Saratov State Medical University, 410012 Saratov, RussiaDepartment of Pathological Anatomy, Saratov State Medical University, 410012 Saratov, RussiaInstitution of Physics, Saratov State University, 410012 Saratov, Russia(1) Background: Upconversion nanoparticles (UCNPs) are a promising tool for biological tissue structure visualization and photodynamic therapy (PDT). The luminescence of such NPs is excited in the spectrum’s near-infrared (NIR) region, while the NPs luminesce in the visible region. Conjugating such NPs with photodynamic dyes that absorb their luminescence makes it possible to increase the depth at which PDT is performed. (2) Methods: We conducted a comprehensive study on the possibility of using NaYF<sub>4</sub>:Er:Yb UCNPs in vivo for imaging and PDT. The NPs were synthesized by a hydrothermal method. The synthesis of NPs with a size of 80 nm and hexagonal structure was demonstrated. (3) Results: The accumulation of NPs in organs after their intravenous injection into rats was studied. The effect of NPs on the shape, size, and degree of aggregation of red blood cells (RBC) was also investigated. (4) Conclusions: The possibility of luminescent visualization of NPs in histological sections and their subcutaneous distribution is demonstrated. All investigated particles showed moderate toxicity, causing mostly reversible changes.https://www.mdpi.com/2304-6732/10/12/1386red blood cellsupconversionnanoparticlesluminescencetoxicitylaserNIR |
| spellingShingle | Anna A. Doronkina Vyacheslav I. Kochubey Anastasia V. Maksutova Alexander B. Pravdin Artem M. Mylnikov Nikita A. Navolokin Irina Yu. Yanina NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells Photonics red blood cells upconversionnanoparticles luminescence toxicity laser NIR |
| title | NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells |
| title_full | NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells |
| title_fullStr | NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells |
| title_full_unstemmed | NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells |
| title_short | NaYF<sub>4</sub>: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells |
| title_sort | nayf sub 4 sub yb er upconversion nanoparticles for imaging effect on red blood cells |
| topic | red blood cells upconversionnanoparticles luminescence toxicity laser NIR |
| url | https://www.mdpi.com/2304-6732/10/12/1386 |
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