Determinants of Phagosomal pH During Host-Pathogen Interactions
The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H+ pumping and counter-ion permeation to offset the countervailing H+ leakage. Despite the best eff...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.624958/full |
| _version_ | 1819056472405835776 |
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| author | Johannes Westman Sergio Grinstein Sergio Grinstein |
| author_facet | Johannes Westman Sergio Grinstein Sergio Grinstein |
| author_sort | Johannes Westman |
| collection | DOAJ |
| description | The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H+ pumping and counter-ion permeation to offset the countervailing H+ leakage. Despite the best efforts of professional phagocytes, however, a number of specialized pathogens survive and even replicate inside phagosomes. In such instances, pathogens target the pH-regulatory machinery of the host cell in an effort to survive inside or escape from phagosomes. This review aims to describe how phagosomal pH is regulated during phagocytosis, why it varies in different types of professional phagocytes and the strategies developed by prototypical intracellular pathogens to manipulate phagosomal pH to survive, replicate, and eventually escape from the phagocyte. |
| first_indexed | 2024-12-21T13:23:57Z |
| format | Article |
| id | doaj.art-d16b31acaf7d484197cca7f4cdfe52f4 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T13:23:57Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d16b31acaf7d484197cca7f4cdfe52f42022-12-21T19:02:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.624958624958Determinants of Phagosomal pH During Host-Pathogen InteractionsJohannes Westman0Sergio Grinstein1Sergio Grinstein2Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, CanadaProgram in Cell Biology, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Biochemistry, University of Toronto, Toronto, ON, CanadaThe ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H+ pumping and counter-ion permeation to offset the countervailing H+ leakage. Despite the best efforts of professional phagocytes, however, a number of specialized pathogens survive and even replicate inside phagosomes. In such instances, pathogens target the pH-regulatory machinery of the host cell in an effort to survive inside or escape from phagosomes. This review aims to describe how phagosomal pH is regulated during phagocytosis, why it varies in different types of professional phagocytes and the strategies developed by prototypical intracellular pathogens to manipulate phagosomal pH to survive, replicate, and eventually escape from the phagocyte.https://www.frontiersin.org/articles/10.3389/fcell.2020.624958/fullpHphagocytosismacrophagepathogenV-ATPaseproton |
| spellingShingle | Johannes Westman Sergio Grinstein Sergio Grinstein Determinants of Phagosomal pH During Host-Pathogen Interactions Frontiers in Cell and Developmental Biology pH phagocytosis macrophage pathogen V-ATPase proton |
| title | Determinants of Phagosomal pH During Host-Pathogen Interactions |
| title_full | Determinants of Phagosomal pH During Host-Pathogen Interactions |
| title_fullStr | Determinants of Phagosomal pH During Host-Pathogen Interactions |
| title_full_unstemmed | Determinants of Phagosomal pH During Host-Pathogen Interactions |
| title_short | Determinants of Phagosomal pH During Host-Pathogen Interactions |
| title_sort | determinants of phagosomal ph during host pathogen interactions |
| topic | pH phagocytosis macrophage pathogen V-ATPase proton |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.624958/full |
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