Hyperin protects against cisplatin-induced liver injury in mice
Abstract Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2017-08-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000800633&tlng=en |
| _version_ | 1819106175488098304 |
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| author | Chengwei Niu Man Ma Xiao Han Zimin Wang Hangyan Li |
| author_facet | Chengwei Niu Man Ma Xiao Han Zimin Wang Hangyan Li |
| author_sort | Chengwei Niu |
| collection | DOAJ |
| description | Abstract Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final intragastrication of hyperin. Twenty-four hours later, blood and liver were collected for further research. Results: A single injection of cisplatin (40 mg/kg) for 24 h significantly increased serum alanine and aspartate aminotransferases (ALT/AST) and gamma glutamyl transferase (GGT) activities, whileas hyperin reversed cisplatin-induced such increases. Liver histopathological examination further demonstrated the protection of hyperin against cisplatin-induced liver injury. Further results showed hyperin reversed cisplatin-induced the increase in content of malondialdehyde (MDA) and the decrease in level of total antioxidant capacity (T-AOC) in liver. Moreover, hyperin increased the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), glutathione-s transferase (GST) in cisplatin-induced liver. Conclusion: Hyperin inhibits cisplatin-induced hepatic oxidative stress, which contributes greatly to the amelioration of cisplatin-induced liver injury in mice. |
| first_indexed | 2024-12-22T02:33:58Z |
| format | Article |
| id | doaj.art-d16bedd173984910bbdba3592fdf0f7e |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T02:33:58Z |
| publishDate | 2017-08-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-d16bedd173984910bbdba3592fdf0f7e2022-12-21T18:41:50ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502017-08-0132863364010.1590/s0102-865020170080000005Hyperin protects against cisplatin-induced liver injury in miceChengwei NiuMan MaXiao HanZimin WangHangyan LiAbstract Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final intragastrication of hyperin. Twenty-four hours later, blood and liver were collected for further research. Results: A single injection of cisplatin (40 mg/kg) for 24 h significantly increased serum alanine and aspartate aminotransferases (ALT/AST) and gamma glutamyl transferase (GGT) activities, whileas hyperin reversed cisplatin-induced such increases. Liver histopathological examination further demonstrated the protection of hyperin against cisplatin-induced liver injury. Further results showed hyperin reversed cisplatin-induced the increase in content of malondialdehyde (MDA) and the decrease in level of total antioxidant capacity (T-AOC) in liver. Moreover, hyperin increased the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), glutathione-s transferase (GST) in cisplatin-induced liver. Conclusion: Hyperin inhibits cisplatin-induced hepatic oxidative stress, which contributes greatly to the amelioration of cisplatin-induced liver injury in mice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000800633&tlng=enCisplatinChemical and Drug Induced Liver InjuryOxidative StressMice. |
| spellingShingle | Chengwei Niu Man Ma Xiao Han Zimin Wang Hangyan Li Hyperin protects against cisplatin-induced liver injury in mice Acta Cirúrgica Brasileira Cisplatin Chemical and Drug Induced Liver Injury Oxidative Stress Mice. |
| title | Hyperin protects against cisplatin-induced liver injury in mice |
| title_full | Hyperin protects against cisplatin-induced liver injury in mice |
| title_fullStr | Hyperin protects against cisplatin-induced liver injury in mice |
| title_full_unstemmed | Hyperin protects against cisplatin-induced liver injury in mice |
| title_short | Hyperin protects against cisplatin-induced liver injury in mice |
| title_sort | hyperin protects against cisplatin induced liver injury in mice |
| topic | Cisplatin Chemical and Drug Induced Liver Injury Oxidative Stress Mice. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000800633&tlng=en |
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