microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models
Neuropathic pain (NP) is poorly managed, and in-depth mechanisms of gene transcriptome alterations in NP pathogenesis are not yet fully understood. To determine microRNA-related molecular mechanisms of NP and their transcriptional regulation in NP, PubMed, Embase, Web of Science and CINAHL Complete...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.780730/full |
| _version_ | 1818754572942835712 |
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| author | Yi-Li Zheng Xuan Su Yu-Meng Chen Jia-Bao Guo Ge Song Zheng Yang Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang |
| author_facet | Yi-Li Zheng Xuan Su Yu-Meng Chen Jia-Bao Guo Ge Song Zheng Yang Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang |
| author_sort | Yi-Li Zheng |
| collection | DOAJ |
| description | Neuropathic pain (NP) is poorly managed, and in-depth mechanisms of gene transcriptome alterations in NP pathogenesis are not yet fully understood. To determine microRNA-related molecular mechanisms of NP and their transcriptional regulation in NP, PubMed, Embase, Web of Science and CINAHL Complete (EBSCO) were searched from inception to April 2021. Commonly dysregulated miRNAs in NP were assessed. The putative targets of these miRNAs were determined using TargetScan, Funrich, Cytoscape and String database. A total of 133 literatures containing miRNA profiles studies and experimentally verify studies were included. Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. Targets on transient receptor potential channels, voltage-gated sodium channels and voltage-gated calcium channels may be harnessed for pain relief. A further delineation of signal processing and modulation in neuronal ensembles is key to achieving therapeutic success in future studies. |
| first_indexed | 2024-12-18T05:25:24Z |
| format | Article |
| id | doaj.art-d16c0ab250244a9bab18cf93814fc075 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-18T05:25:24Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-d16c0ab250244a9bab18cf93814fc0752022-12-21T21:19:33ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-01-01810.3389/fmolb.2021.780730780730microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent ModelsYi-Li Zheng0Xuan Su1Yu-Meng Chen2Jia-Bao Guo3Ge Song4Zheng Yang5Pei-Jie Chen6Xue-Qiang Wang7Xue-Qiang Wang8Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaThe Second School of Clinical Medical, Xuzhou Medical University, Xuzhou, ChinaDepartment of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, ChinaNeuropathic pain (NP) is poorly managed, and in-depth mechanisms of gene transcriptome alterations in NP pathogenesis are not yet fully understood. To determine microRNA-related molecular mechanisms of NP and their transcriptional regulation in NP, PubMed, Embase, Web of Science and CINAHL Complete (EBSCO) were searched from inception to April 2021. Commonly dysregulated miRNAs in NP were assessed. The putative targets of these miRNAs were determined using TargetScan, Funrich, Cytoscape and String database. A total of 133 literatures containing miRNA profiles studies and experimentally verify studies were included. Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. Targets on transient receptor potential channels, voltage-gated sodium channels and voltage-gated calcium channels may be harnessed for pain relief. A further delineation of signal processing and modulation in neuronal ensembles is key to achieving therapeutic success in future studies.https://www.frontiersin.org/articles/10.3389/fmolb.2021.780730/fullbioinformatics analysismiRNAneuropathic painfunctional enrichment analysisbiomarker |
| spellingShingle | Yi-Li Zheng Xuan Su Yu-Meng Chen Jia-Bao Guo Ge Song Zheng Yang Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models Frontiers in Molecular Biosciences bioinformatics analysis miRNA neuropathic pain functional enrichment analysis biomarker |
| title | microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models |
| title_full | microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models |
| title_fullStr | microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models |
| title_full_unstemmed | microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models |
| title_short | microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models |
| title_sort | microrna based network and pathway analysis for neuropathic pain in rodent models |
| topic | bioinformatics analysis miRNA neuropathic pain functional enrichment analysis biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.780730/full |
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