Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic Diseases

Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic Diseases

The hexosamine biosynthetic pathway (HBP) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway are considered as nutrient sensors that regulate several essential biological processes. The hexosamine biosynthetic pathway produces uridine diphosphate...

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Bibliographic Details
Main Authors: Ninon Very, Anne-Sophie Vercoutter-Edouart, Tony Lefebvre, Stéphan Hardivillé, Ikram El Yazidi-Belkoura
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
O-GlcNAcylation
PI3K/AKT/mTOR
cancer
diabetes
cardiovascular
neurodegenerative diseases
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00602/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00602/full

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