Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells
The complexity of sensory receptive fields increases from one synaptic stage to the next. In many cases, increased complexity is achieved through spatiotemporal interactions between convergent excitatory and inhibitory inputs. Here, we present evidence that direction selectivity (DS), a complex emer...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717300633 |
| _version_ | 1819267623124205568 |
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| author | James W. Fransen Bart G. Borghuis |
| author_facet | James W. Fransen Bart G. Borghuis |
| author_sort | James W. Fransen |
| collection | DOAJ |
| description | The complexity of sensory receptive fields increases from one synaptic stage to the next. In many cases, increased complexity is achieved through spatiotemporal interactions between convergent excitatory and inhibitory inputs. Here, we present evidence that direction selectivity (DS), a complex emergent receptive field property of retinal starburst amacrine cells (SACs), is generated by spatiotemporal interactions between functionally diverse excitatory inputs. Electrophysiological whole-cell recordings from ON and OFF SACs show distinct temporal differences in excitation following proximal compared with distal stimulation of their receptive fields. Distal excitation is both faster and more transient, ruling out passive filtering by the dendrites and indicating a task-specific specialization. Model simulations demonstrate that this specific organization of excitation generates robust DS responses in SACs, consistent with elementary motion detector models. These results indicate that selective integration of spatiotemporally patterned excitation is a computational mechanism for motion detection in the mammalian retina. |
| first_indexed | 2024-12-23T21:20:06Z |
| format | Article |
| id | doaj.art-d16d4670cd9e4034b55ede80956c3eda |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-23T21:20:06Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-d16d4670cd9e4034b55ede80956c3eda2022-12-21T17:30:47ZengElsevierCell Reports2211-12472017-02-011861356136510.1016/j.celrep.2017.01.026Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine CellsJames W. Fransen0Bart G. Borghuis1Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USADepartment of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USAThe complexity of sensory receptive fields increases from one synaptic stage to the next. In many cases, increased complexity is achieved through spatiotemporal interactions between convergent excitatory and inhibitory inputs. Here, we present evidence that direction selectivity (DS), a complex emergent receptive field property of retinal starburst amacrine cells (SACs), is generated by spatiotemporal interactions between functionally diverse excitatory inputs. Electrophysiological whole-cell recordings from ON and OFF SACs show distinct temporal differences in excitation following proximal compared with distal stimulation of their receptive fields. Distal excitation is both faster and more transient, ruling out passive filtering by the dendrites and indicating a task-specific specialization. Model simulations demonstrate that this specific organization of excitation generates robust DS responses in SACs, consistent with elementary motion detector models. These results indicate that selective integration of spatiotemporally patterned excitation is a computational mechanism for motion detection in the mammalian retina.http://www.sciencedirect.com/science/article/pii/S2211124717300633mouseretinabipolar cellstarburst amacrine cellNMDA receptordirection selectivitycircular white noisereverse correlation |
| spellingShingle | James W. Fransen Bart G. Borghuis Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells Cell Reports mouse retina bipolar cell starburst amacrine cell NMDA receptor direction selectivity circular white noise reverse correlation |
| title | Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells |
| title_full | Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells |
| title_fullStr | Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells |
| title_full_unstemmed | Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells |
| title_short | Temporally Diverse Excitation Generates Direction-Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells |
| title_sort | temporally diverse excitation generates direction selective responses in on and off type retinal starburst amacrine cells |
| topic | mouse retina bipolar cell starburst amacrine cell NMDA receptor direction selectivity circular white noise reverse correlation |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717300633 |
| work_keys_str_mv | AT jameswfransen temporallydiverseexcitationgeneratesdirectionselectiveresponsesinonandofftyperetinalstarburstamacrinecells AT bartgborghuis temporallydiverseexcitationgeneratesdirectionselectiveresponsesinonandofftyperetinalstarburstamacrinecells |