The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep
Milk is an integral and therefore complex structural element of mammalian nutrition. Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex as the mammary gland, the organ responsible for this biochemical activity. Nutrition, genetics, epigenetics, disease p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/7/4/78 |
| _version_ | 1827670631358922752 |
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| author | Artem P. Dysin Olga Y. Barkova Marina V. Pozovnikova |
| author_facet | Artem P. Dysin Olga Y. Barkova Marina V. Pozovnikova |
| author_sort | Artem P. Dysin |
| collection | DOAJ |
| description | Milk is an integral and therefore complex structural element of mammalian nutrition. Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex as the mammary gland, the organ responsible for this biochemical activity. Nutrition, genetics, epigenetics, disease pathogens, climatic conditions, and other environmental variables all impact breast productivity. In the last decade, the number of studies devoted to epigenetics has increased dramatically. Reports are increasingly describing the direct participation of microRNAs (miRNAs), small noncoding RNAs that regulate gene expression post-transcriptionally, in the regulation of mammary gland development and function. This paper presents a summary of the current state of knowledge about the roles of miRNAs in mammary gland development, health, and functions, particularly during lactation. The significance of miRNAs in signaling pathways, cellular proliferation, and the lipid metabolism in agricultural ruminants, which are crucial in light of their role in the nutrition of humans as consumers of dairy products, is discussed. |
| first_indexed | 2024-03-10T03:25:46Z |
| format | Article |
| id | doaj.art-d16fc93c183b4b07b3a8fc480da53dfe |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-10T03:25:46Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-d16fc93c183b4b07b3a8fc480da53dfe2023-11-23T09:53:12ZengMDPI AGNon-Coding RNA2311-553X2021-12-01747810.3390/ncrna7040078The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and SheepArtem P. Dysin0Olga Y. Barkova1Marina V. Pozovnikova2Russian Research Institute of Farm Animal Genetics and Breeding–Branch of the L. K. Ernst Federal Science Center for Animal Husbandry, Pushkin, 196625 St. Petersburg, RussiaRussian Research Institute of Farm Animal Genetics and Breeding–Branch of the L. K. Ernst Federal Science Center for Animal Husbandry, Pushkin, 196625 St. Petersburg, RussiaRussian Research Institute of Farm Animal Genetics and Breeding–Branch of the L. K. Ernst Federal Science Center for Animal Husbandry, Pushkin, 196625 St. Petersburg, RussiaMilk is an integral and therefore complex structural element of mammalian nutrition. Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex as the mammary gland, the organ responsible for this biochemical activity. Nutrition, genetics, epigenetics, disease pathogens, climatic conditions, and other environmental variables all impact breast productivity. In the last decade, the number of studies devoted to epigenetics has increased dramatically. Reports are increasingly describing the direct participation of microRNAs (miRNAs), small noncoding RNAs that regulate gene expression post-transcriptionally, in the regulation of mammary gland development and function. This paper presents a summary of the current state of knowledge about the roles of miRNAs in mammary gland development, health, and functions, particularly during lactation. The significance of miRNAs in signaling pathways, cellular proliferation, and the lipid metabolism in agricultural ruminants, which are crucial in light of their role in the nutrition of humans as consumers of dairy products, is discussed.https://www.mdpi.com/2311-553X/7/4/78miRNAmammary glandfarm animalslactation |
| spellingShingle | Artem P. Dysin Olga Y. Barkova Marina V. Pozovnikova The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep Non-Coding RNA miRNA mammary gland farm animals lactation |
| title | The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep |
| title_full | The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep |
| title_fullStr | The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep |
| title_full_unstemmed | The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep |
| title_short | The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep |
| title_sort | role of micrornas in the mammary gland development health and function of cattle goats and sheep |
| topic | miRNA mammary gland farm animals lactation |
| url | https://www.mdpi.com/2311-553X/7/4/78 |
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