Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages
Abstract This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively)....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31682-w |
| _version_ | 1827974594656468992 |
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| author | Izabela N. F. Almeida Elise Taniguchi Cecília Victoria Agapito Tito Diego Torres Dias Michele Ushida Syril Dorairaj Robert Ritch Sérgio H. Teixeira Augusto Paranhos Carolina P. B. Gracitelli Cristiane Kayser Tiago Santos Prata |
| author_facet | Izabela N. F. Almeida Elise Taniguchi Cecília Victoria Agapito Tito Diego Torres Dias Michele Ushida Syril Dorairaj Robert Ritch Sérgio H. Teixeira Augusto Paranhos Carolina P. B. Gracitelli Cristiane Kayser Tiago Santos Prata |
| author_sort | Izabela N. F. Almeida |
| collection | DOAJ |
| description | Abstract This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively). The 33 enrolled patients (mean age, 62.3 ± 13 years) were classified as LTDH or HTDH if they presented at the time of DH detection an intraocular pressure (IOP) < 16 mmHg or ≥ 16 mmHg, respectively. Demographic and ophthalmological data, ET-1 concentrations, LDI (before and 1, 10, and 20 min after cold stimulation), and nailfold capillaroscopy findings were evaluated. The ET-1 blood level was 65% higher in the LTDH (2.27 ± 1.46 pg/ml) than in the HTDH (1.37 ± 0.57 pg/ml; p = 0.03) group. Moreover, there was a statistically significant negative correlation between ET-1 blood concentration and IOP at the time of DH detection (r = −0.45, p = 0.02). Blood flow measurements 10 and 20 min after cold stimulation were lower in the LTDH group than in the HTDH group (p < 0.01). Patients developing DH with lower IOPs have higher ET-1 blood levels and more peripheral vascular dysfunction as estimated by LDI than those with higher IOPs. These findings suggest that distinct underlying mechanisms may be involved in patients developing DH within different IOP ranges. |
| first_indexed | 2024-04-09T19:56:54Z |
| format | Article |
| id | doaj.art-d1700d87645f42ee93a34bb671fa9692 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:56:54Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d1700d87645f42ee93a34bb671fa96922023-04-03T05:27:42ZengNature PortfolioScientific Reports2045-23222023-03-011311910.1038/s41598-023-31682-wVascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhagesIzabela N. F. Almeida0Elise Taniguchi1Cecília Victoria Agapito Tito2Diego Torres Dias3Michele Ushida4Syril Dorairaj5Robert Ritch6Sérgio H. Teixeira7Augusto Paranhos8Carolina P. B. Gracitelli9Cristiane Kayser10Tiago Santos Prata11Department of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloRheumatology Division, Federal University of Sao PauloDepartment of Ophthalmology, Federal University of São PauloGlaucoma Unit, Hospital Medicina dos OlhosDepartment of Ophthalmology, Mayo ClinicEinhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount SinaiDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloRheumatology Division, Federal University of Sao PauloDepartment of Ophthalmology, Federal University of São PauloAbstract This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively). The 33 enrolled patients (mean age, 62.3 ± 13 years) were classified as LTDH or HTDH if they presented at the time of DH detection an intraocular pressure (IOP) < 16 mmHg or ≥ 16 mmHg, respectively. Demographic and ophthalmological data, ET-1 concentrations, LDI (before and 1, 10, and 20 min after cold stimulation), and nailfold capillaroscopy findings were evaluated. The ET-1 blood level was 65% higher in the LTDH (2.27 ± 1.46 pg/ml) than in the HTDH (1.37 ± 0.57 pg/ml; p = 0.03) group. Moreover, there was a statistically significant negative correlation between ET-1 blood concentration and IOP at the time of DH detection (r = −0.45, p = 0.02). Blood flow measurements 10 and 20 min after cold stimulation were lower in the LTDH group than in the HTDH group (p < 0.01). Patients developing DH with lower IOPs have higher ET-1 blood levels and more peripheral vascular dysfunction as estimated by LDI than those with higher IOPs. These findings suggest that distinct underlying mechanisms may be involved in patients developing DH within different IOP ranges.https://doi.org/10.1038/s41598-023-31682-w |
| spellingShingle | Izabela N. F. Almeida Elise Taniguchi Cecília Victoria Agapito Tito Diego Torres Dias Michele Ushida Syril Dorairaj Robert Ritch Sérgio H. Teixeira Augusto Paranhos Carolina P. B. Gracitelli Cristiane Kayser Tiago Santos Prata Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages Scientific Reports |
| title | Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages |
| title_full | Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages |
| title_fullStr | Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages |
| title_full_unstemmed | Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages |
| title_short | Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages |
| title_sort | vascular parameters and endothelin 1 measurements in glaucoma patients with low and high tension optic disc hemorrhages |
| url | https://doi.org/10.1038/s41598-023-31682-w |
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