Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions
Adhesion is crucial for the infective lifestyles of bacterial pathogens. Adhesion to non-living surfaces, other microbial cells, and components of the biofilm extracellular matrix are crucial for biofilm formation and integrity, plus adherence to host factors constitutes a first step leading to an i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/2/454 |
| _version_ | 1797477818275201024 |
|---|---|
| author | Albertus Viljoen Yves F. Dufrêne Jérôme Nigou |
| author_facet | Albertus Viljoen Yves F. Dufrêne Jérôme Nigou |
| author_sort | Albertus Viljoen |
| collection | DOAJ |
| description | Adhesion is crucial for the infective lifestyles of bacterial pathogens. Adhesion to non-living surfaces, other microbial cells, and components of the biofilm extracellular matrix are crucial for biofilm formation and integrity, plus adherence to host factors constitutes a first step leading to an infection. Adhesion is, therefore, at the core of pathogens’ ability to contaminate, transmit, establish residency within a host, and cause an infection. Several mycobacterial species cause diseases in humans and animals with diverse clinical manifestations. <i>Mycobacterium tuberculosis</i>, which enters through the respiratory tract, first adheres to alveolar macrophages and epithelial cells leading up to transmigration across the alveolar epithelium and containment within granulomas. Later, when dissemination occurs, the bacilli need to adhere to extracellular matrix components to infect extrapulmonary sites. Mycobacteria causing zoonotic infections and emerging nontuberculous mycobacterial pathogens follow divergent routes of infection that probably require adapted adhesion mechanisms. New evidence also points to the occurrence of mycobacterial biofilms during infection, emphasizing a need to better understand the adhesive factors required for their formation. Herein, we review the literature on tuberculous and nontuberculous mycobacterial adhesion to living and non-living surfaces, to themselves, to host cells, and to components of the extracellular matrix. |
| first_indexed | 2024-03-09T21:23:09Z |
| format | Article |
| id | doaj.art-d1701d8e6b3b41879d0a27f4e461c239 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T21:23:09Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d1701d8e6b3b41879d0a27f4e461c2392023-11-23T21:16:27ZengMDPI AGMicroorganisms2076-26072022-02-0110245410.3390/microorganisms10020454Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand InteractionsAlbertus Viljoen0Yves F. Dufrêne1Jérôme Nigou2Louvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, BelgiumInstitut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, FranceAdhesion is crucial for the infective lifestyles of bacterial pathogens. Adhesion to non-living surfaces, other microbial cells, and components of the biofilm extracellular matrix are crucial for biofilm formation and integrity, plus adherence to host factors constitutes a first step leading to an infection. Adhesion is, therefore, at the core of pathogens’ ability to contaminate, transmit, establish residency within a host, and cause an infection. Several mycobacterial species cause diseases in humans and animals with diverse clinical manifestations. <i>Mycobacterium tuberculosis</i>, which enters through the respiratory tract, first adheres to alveolar macrophages and epithelial cells leading up to transmigration across the alveolar epithelium and containment within granulomas. Later, when dissemination occurs, the bacilli need to adhere to extracellular matrix components to infect extrapulmonary sites. Mycobacteria causing zoonotic infections and emerging nontuberculous mycobacterial pathogens follow divergent routes of infection that probably require adapted adhesion mechanisms. New evidence also points to the occurrence of mycobacterial biofilms during infection, emphasizing a need to better understand the adhesive factors required for their formation. Herein, we review the literature on tuberculous and nontuberculous mycobacterial adhesion to living and non-living surfaces, to themselves, to host cells, and to components of the extracellular matrix.https://www.mdpi.com/2076-2607/10/2/454mycobacteriumhost-pathogen interactionadhesionbacterial envelopeadhesintuberculosis |
| spellingShingle | Albertus Viljoen Yves F. Dufrêne Jérôme Nigou Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions Microorganisms mycobacterium host-pathogen interaction adhesion bacterial envelope adhesin tuberculosis |
| title | Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions |
| title_full | Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions |
| title_fullStr | Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions |
| title_full_unstemmed | Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions |
| title_short | Mycobacterial Adhesion: From Hydrophobic to Receptor-Ligand Interactions |
| title_sort | mycobacterial adhesion from hydrophobic to receptor ligand interactions |
| topic | mycobacterium host-pathogen interaction adhesion bacterial envelope adhesin tuberculosis |
| url | https://www.mdpi.com/2076-2607/10/2/454 |
| work_keys_str_mv | AT albertusviljoen mycobacterialadhesionfromhydrophobictoreceptorligandinteractions AT yvesfdufrene mycobacterialadhesionfromhydrophobictoreceptorligandinteractions AT jeromenigou mycobacterialadhesionfromhydrophobictoreceptorligandinteractions |