Modelling renal defects in Bardet-Biedl syndrome patients using human iPS cells

Modelling renal defects in Bardet-Biedl syndrome patients using human iPS cells

Bardet-Biedl syndrome (BBS) is a ciliopathy with pleiotropic effects on multiple tissues, including the kidney. Here we have compared renal differentiation of iPS cells from healthy and BBS donors. High content image analysis of WT1-expressing kidney progenitors showed that cell proliferation, diffe...

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Bibliographic Details
Main Authors: James Williams, Chloe Hurling, Sabrina Munir, Peter Harley, Carolina Barcellos Machado, Ana-Maria Cujba, Mario Alvarez-Fallas, Davide Danovi, Ivo Lieberam, Rocio Sancho, Philip Beales, Fiona M. Watt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
iPSC (induced pluripotent stem cell)
kidney
ciliopathy
CRISPR
Bardet-Biedl syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1163825/full

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