The Use of Sonophoresis in the Administration of Drugs Throughout the Skin
Abstract Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin incr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2009-04-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/5045 |
| _version_ | 1797717638124666880 |
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| author | Jose Juan Escobar-Chavez Dalia Bonilla-Martínez Martha Angélica Villegas-González Isabel Marlen Rodríguez-Cruz Clara Luisa Domínguez-Delgado |
| author_facet | Jose Juan Escobar-Chavez Dalia Bonilla-Martínez Martha Angélica Villegas-González Isabel Marlen Rodríguez-Cruz Clara Luisa Domínguez-Delgado |
| author_sort | Jose Juan Escobar-Chavez |
| collection | DOAJ |
| description | Abstract
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin.
Ultrasound has been used extensively for medical diagnostics and to a certain extent in medical therapy (physiotherapy, ultrasonic surgery, hyperthermia). Nevertheless, it has only recently become popular as a technique to enhance drug release from drug delivery systems. A number of studies suggest the use of ultrasound as an external mean of delivering drugs at increased rates and at desired times.
This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and trends in the field of topical and transdermal delivery. |
| first_indexed | 2024-03-12T08:39:10Z |
| format | Article |
| id | doaj.art-d1723453705149918ff8a3c62e217b3d |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T08:39:10Z |
| publishDate | 2009-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-d1723453705149918ff8a3c62e217b3d2023-09-02T17:02:27ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262009-04-0112110.18433/J3C30DThe Use of Sonophoresis in the Administration of Drugs Throughout the SkinJose Juan Escobar-Chavez0Dalia Bonilla-MartínezMartha Angélica Villegas-GonzálezIsabel Marlen Rodríguez-CruzClara Luisa Domínguez-DelgadoUniversidad Nacional Autonoma de MexicoAbstract Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. Ultrasound has been used extensively for medical diagnostics and to a certain extent in medical therapy (physiotherapy, ultrasonic surgery, hyperthermia). Nevertheless, it has only recently become popular as a technique to enhance drug release from drug delivery systems. A number of studies suggest the use of ultrasound as an external mean of delivering drugs at increased rates and at desired times. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and trends in the field of topical and transdermal delivery.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/5045 |
| spellingShingle | Jose Juan Escobar-Chavez Dalia Bonilla-Martínez Martha Angélica Villegas-González Isabel Marlen Rodríguez-Cruz Clara Luisa Domínguez-Delgado The Use of Sonophoresis in the Administration of Drugs Throughout the Skin Journal of Pharmacy & Pharmaceutical Sciences |
| title | The Use of Sonophoresis in the Administration of Drugs Throughout the Skin |
| title_full | The Use of Sonophoresis in the Administration of Drugs Throughout the Skin |
| title_fullStr | The Use of Sonophoresis in the Administration of Drugs Throughout the Skin |
| title_full_unstemmed | The Use of Sonophoresis in the Administration of Drugs Throughout the Skin |
| title_short | The Use of Sonophoresis in the Administration of Drugs Throughout the Skin |
| title_sort | use of sonophoresis in the administration of drugs throughout the skin |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/5045 |
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